Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:84150 Adarichev VA, et al., Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum. 2003 Jun;48(6):1708-20
• ID
  MGI:5576021

Genes

Gene	Assay Type
Pgia3	resistance/susceptibility
D7Mit120	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 559 proteoglycan-immunized (BALB/cCrl x DBA/2Crl)F2 animals to detect QTLs associated with arthritis susceptibility, severity, and onset. BALB/cCrl females are 100% susceptible to proteoglycan-induced arthritis (PGIA) whereas DBA/2Crl males are resistant. F1 hybrid males and females are also resistant to PGIA.
  
  Several previously identified PGIA loci were confirmed in this study. These include Pgia1, Pgia4, Pgia6, Pgia7 Pgia8, Pgia9, Pgia12.
  
  The authors refer to QTL Pgia21 on Chromosome 7. Pgia21 was originally mapped using (BALB/cCrl x DBA/1J)F2 mice in J:82081 which differs from the cross used here.
  
  We have equated the QTL identified here on Chr 7 with Pgia3, also mapped using a (BALB/cCrl x DBA/2Crl)F2 cross in J:66460 in 1999. Pgia3 maps to mouse chromosome 7 at D7Mit120 with LOD=4.8 for disease susceptibility in female mice; LOD=2.5 for disease onset in all F2 mice; and LOD=3.9 for severity in all F2 mice. The Pgia3 interval spanned 23-44cM on chr 7.