Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:84150 Adarichev VA, et al., Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis. Arthritis Rheum. 2003 Jun;48(6):1708-20
• ID
  MGI:5576025

Genes

Gene	Assay Type
Pgia1	resistance/susceptibility
D1Mit445	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 559 proteoglycan-immunized (BALB/cCrl x DBA/2Crl)F2 animals to detect QTLs associated with arthritis susceptibility, severity, and onset. BALB/cCrl females are 100% susceptible to proteoglycan-induced arthritis (PGIA) whereas DBA/2Crl males are resistant. F1 hybrid males and females are also resistant to PGIA.
  
  Several previously identified PGIA loci were confirmed in this study. These include Pgia1, Pgia4, Pgia6, Pgia7 Pgia8, Pgia9,and Pgia12.
  
  Pgia1 mapped to mouse chromosome 1 with LOD=3.1 at D1Mit445 for arthritis severity in male mice. The Pgia1 interval spanned 33-106cM on chr 1.