Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:33778 Ewart SL, et al., Airway hyperresponsiveness to acetylcholine: segregation analysis and evidence for linkage to murine chromosome 6. Am J Respir Cell Mol Biol. 1996 May;14(5):487-95
• ID
  MGI:5607929

Genes

Gene	Assay Type	Description
Bhr5	resistance/susceptibility	yes
D6Mit62a	PCR amplified length variant	yes
D6Mit13	PCR amplification	yes

Notes

• Experiment
  Using the progeny from the hyperresponsive A/J mice crossed with the hyporepsonsive C3H/HeJ mice, segregation analyses indicated a major QTL locus, acting additively with a polygenic effect, on Chromosome 6.
  
  Using linkage analysis 196 mice from a (C3H/HeJx A/J)F1 x A/J backcross revealed a QTL, Bhr5, with significant linkage for ACh-induced AHR within the interval spanning markers D6Mit62a and D6Mit13, LOD=3.11.
  
  A/J alleles were associated with significantly greater airway responsiveness than were C3H/HeJ alleles. Candidate genes mapping to this region include the Il5 receptor.