Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:208464 Kayashima Y, et al., Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice. PLoS One. 2014;9(2):e88274
• ID
  MGI:5644291

Genes

Gene	Assay Type
Ath46	susceptibility/resistance

Notes

• Experiment
  Linkage analysis was performed on 137 female (129S6/SvEvTac-Apoe^tm4Mae x D2.129P2(B6)-Apoe^tm1Unc/J)F2 intercross mice using 170 SNP markers to identify QTL associated with atherosclerotic susceptibility (atherosclerotic lesion size at aortic root). Parental strain D2.129P2(B6)-Apoe exhibits higher incidence of atherosclerosis when compared to 129S6/SvEvTac-Apoe.
  
  QTL Ath46 maps to 106 - 150 Mb (61 - 86 cM) on Chromosome 2 with a peak LOD score of 3.9 at 139 Mb (79 cM) in linkage with atheroscleroticlesion size. D2.129P2(B6)-Apoe alleles confer increased susceptibility to atherosclerotic lesion size.