Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  19
• Reference
  J:163229 Berghout J, et al., Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19. Genes Immun. 2010 Jun;11(4):310-8
• ID
  MGI:5661590

Genes

Gene	Assay Type
Berr5	susceptibility/resistance

Notes

• Experiment
  Linkage analysis was performed on 257 (C57BL/6 BALB/c)F2 intercross mice using 252 markers to identify QTL associated with susceptibility to Cerebral malaria (survival time).
  
  QTL Berr5 maps to 29.3 - 41.3 Mb on Chromosome 19 with a peak LOD score of 4.69 at 32.3 Mb in linkage with Cerebral malaria susceptibility. C57BL/6 alleles convey susceptiblity to Cerebral malaria, with the majority of animals dying during the early cerebral phase of infection. Conversely, BALB/c mice were resistant to PbA-induced CM, with >75-80% of the animals surviving the cerebral phase. BALB/c alleles convey increased survival through the cerebral phase of infection but have no quantitative effect on parasitemia during the later, anemic phase.