Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:197549 Rowlan JS, et al., New quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains. Physiol Genomics. 2013 Apr 16;45(8):332-42
• ID
  MGI:5689899

Genes

Gene	Assay Type
Cath2	visible phenotype

Notes

• Experiment
  Linkage analysis was performed on 266 female (B6.129P2-Apoe^tm1Unc/J x C.129P2(B6)-Apoe^tm1Unc)F2 intercross mice using 130 SNP markers to identify QTL associated with susceptibility to athleroscotic carotid lesion. QTL mapping was performed using a nonparametric method.
  
  QTL Cath2 maps to 48.46 - 66.68 cM on Chromosome 5 with a peak LOD score of 6.615 at 56.68 cM in linkage with athleroscotic carotid lesion incidence. B6.129P2-Apoe^tm1Unc/J alleles confer increased susceptibility to athleroscotic carotid lesion with a dominant mode of inheritance.