Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:73060 Roper RJ, et al., Genetic control of susceptibility to experimental Lyme arthritis is polygenic and exhibits consistent linkage to multiple loci on chromosome 5 in four independent mouse crosses. Genes Immun. 2001 Nov;2(7):388-97
• ID
  MGI:5693955

Genes

Gene	Assay Type
Bbaa4	resistance/susceptibility
D11Mit350

Notes

• Experiment
  Composite interval mapping (CIM) was used for localization of QTL involved in modulating response to infection with Borrelia burgdorferi. Parental strains C3H/HeN and C3H/HeJ are susceptible to B.burgdorferi-induced arthritis whereas parental strains C57BL/6N and BALB/cAnN are resistant. Four different backcrosses and the reanalysis of a previous intercross were performed.
  
  The reanalysis of the (C57BL/6N X C3H/HeN)F2 intercross also confirmed the previoulsy identified Bbaa4 QTL on Chr 11. Using CIM Bbaa4, linked to histopathology, mapped to 34.5 cM with marker D11Mit350, LRT=18.8. [Table 3.]