Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  13
• Reference
  J:182797 Wang SS, et al., Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice. Circ Cardiovasc Genet. 2009 Dec;2(6):573-82
• ID
  MGI:5697480

Genes

Gene	Assay Type
Mcal2	visible phenotype

Notes

• Experiment
  Linkage analysis was performed on 332 (B6.129P2-Apoe^tm1Unc/J x C3.129P2(B6)-Apoe^tm1Unc)F2 intercross mice using 1347 markers to identify QTL associated with aortic medial calcification. Parental strain C3H/HeJ displays higher susceptibility to aortic medial disruption than C57BL/6J.
  
  QTL Mcal2 maps to 51.9 - 113.5 Mb on Chromosome 13 with a peak LOD score of 3.43 (sex-covariate) or 4.41 (sex-interaction) at 110.2 cM in linkage with aortic medial calcification. C57BL/6J alleles confer increased susceptibility to aortic medial calcification at the Mcal2 locus.