Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:106112 Smith JD, et al., Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):597-603
• ID
  MGI:5697694

Genes

Gene	Assay Type
Eosn1	visible phenotype
Eosn3	visible phenotype

Notes

• Experiment
  Linkage analysis was performed on 209 (AKR.129P2(B6)-Apoe^tm1Bres x D2.129P2(B6)-Apoe^tm1Bres)F2 intercross mice (95 female, 114 male) using 1967 markers to identify QTL associated with percent eosinophils as measured by complete bood count. The cross was generated with the intent to identify QTL related to atherosclerosis. Parental strains AKR/J and DBA/2J are atherosclerosis resistant and sensitive, respectively.
  
  QTL Eosn1 maps to Chromosome 7 with a peak LOD score of 3.21 at marker rs4226520 (23 Mb) in linkage with eosinophil percentage via CBC. AKR/J alleles confer increased susceptibility to percent eosinophils at the Eosn1 locus.
  
  Eosn1 is a female-specific QTL. Genetic mapping was performed relative to NCBI mouse genome build 34.
  
  QTL Eosn3 also maps to Chromosome 7, with a peak LOD score of 4.46 at marker rs4226520 (23 Mb) in linkage with eosinophil percentage via CBC. AKR/J alleles confer increased susceptibility to percent eosinophils at the Eosn2 locus. Genetic mapping was performed relative to NCBI mouse genome build 34 and sex was used as an interactive covariate.