Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  13
• Reference
  J:106112 Smith JD, et al., Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):597-603
• ID
  MGI:5697695

Genes

Gene	Assay Type
Eosn2	visible phenotype

Notes

• Experiment
  Linkage analysis was performed on 209 (AKR.129P2(B6)-Apoe^tm1Bres x D2.129P2(B6)-Apoe^tm1Bres)F2 intercross mice (95 female, 114 male) using 1967 markers to identify QTL associated with percent eosinophils as measured by complete bood count. The crosswas generated with the intent to identify QTL related to atherosclerosis. Parental strains AKR/J and DBA/2J are atherosclerosis resistant and sensitive, respectively.
  
  QTL Eosn2 maps to Chromosome 13 with a peak LOD score of 4.49 at marker rs6307428 (17 Mb) in linkage with eosinophil percentage via CBC. AKR/J alleles confer increased susceptibility to percent eosinophils at the Eosn2 locus. Genetic mapping was performed relative to NCBI mouse genome build 34 and sex was used as an interactive covariate.