Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  14
• Reference
  J:106112 Smith JD, et al., Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan. Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):597-603
• ID
  MGI:5703015

Genes

Gene	Assay Type
Hgb2	resistance/susceptibility

Notes

• Experiment
  Linkage analysis was performed on 209 (AKR.129P2(B6)-Apoe^tm1Bres x D2.129P2(B6)-Apoe^tm1Bres)F2 intercross mice (95 female, 114 male) using 1967 markers. The cross was generated to identify QTL related to atherosclerosis. Parental strains AKR/J and DBA/2J are atherosclerosis resistant and sensitive, respectively. Additional QTL were identified for body weight; total cholesterol and blood count parameters. Genome-wide probability values were assigned as p<0.05 =significant; p<0.25 = likely, and p>.025 as suggestive.
  
  Total cholesterol QTL were identified on Chromosomes 10 and 13.
  A significant male specific QTL, Chol15, cholesterol 15, mapped to mouse chromosome 13 with peak marker rs6244558 with a LOD=3.85, p<0.05. DBA/2J alleles conferred higher cholesterol at this locus.
  QTL Chol18, cholesterol 18, in both sexes combined, mapped to Chromosome 13 with peak marker rs6244558 with a LOD=4.67, p<0.15. DBA/2J alleles conferred higher cholesterol at this locus in a single sex analysis.
  QTL Chol16, cholesterol 16, also male specific mapped to Chromosome 10 with peak marker rs13459120 with a LOD=3.47, p<0.10. The AKR/J alleles conferred higher cholesterol at this locus.
  
  A significant male specific QTL, Wbc1, white blood count 1, mapped to Chromosome 8 to peak marker rs13479943 with a LOD=4.05, p<0.05.
  Wbc2, white blood cell count 2, mapped in both sexes also mapped to Chromosome 8, peaking at marker rs13479941 with a LOD=6.22, p<0.01.
  AKR/J alleles conferred an increase in white blood cell count at both Wbc1 and Wbc2.
  
  A significant QTL, Rbc1, red blood cell count 1, mapped in both male and female mice mapped to Chromosome 4, peaking at marker rs3657938 with a LOD=4.67, p<0.05. DBA/2J alleles conferred higher red blood cell count at this locus.
  
  A QTL, Mono1, monocyte differential 1, mapped in both sexes, mapped to Chromosome 5, peaking at marker rs6370004 with a LOD=3.01, p<0.25. AKR/2J alleles conferred an increased percentage of monocytes at this locus.
  
  A QTL, Hct1, hematocrit 1, mapped in both sexes, mapped to Chromosome 4, peaking at marker, rs3657938 with a LOD=3.89, p<0.10.
  
  A QTL Hgb1, hemaglobin 1, also mapped in both sexes to Chromosome 4, peaking at marker rs3657938 with a LOD=3.97, p<0.10.
  QTL Hgb2, hemaglobin 2, also mapped in both sexes, mapped to chromosome 14, LOD=3.17 at marker rs13482409, p<0.20.
  DBA/2J alleles confer increased hemoglobin at both Hgb1 abd Hgb2.
  
  QTL Lymph1, lymphocyte differential 1, a male specific QTL, mapped to Chromosome 2 peaking at marker rs13476557 with a LOD=3.28, p<0.15. AKR/J alleles confer an increased percentage of lymphocytes at this locus.
  QTL Lymph2, lymphocyte differential 2, also male specific, mapped to Chromosome 17 peaking at maker rs13483042 with a LOD=3.07, p<0.25. DBA/2J alleles confer and increased percentage of lymphocytes at this locus.
  QTL Lymph3, lymphocyte differential 3, also male specific, mapped to Chromosome 4 peaking at marker rs8260738 with a LOD=3.01, p<0.25. DBA/2J alleles confer and increased percentage of lymphocytes at this locus.
  QTL Lymph4, lymphocyte differential 4, mapped in both sexes to Chromosome 17 at peak marker rs13483042 with a LOD=3.69, p<0.10. DBA/2J alleles confer and increased percentage of lymphocytes at this locus.
  QTL Lymph5, lymphocyte differential 5, also mapped in both sexes to Chromosome 2 at peak marker rs13476534 with a LOD=3.05, p<0.25.AKR/J alleles confer an increased percentage of lymphocytes at this locus.