Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  18
• Reference
  J:108764 Havelkova H, et al., Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes Immun. 2006 Apr;7(3):220-33
• ID
  MGI:5752967

Genes

Gene	Assay Type
Lmr29	resistance/susceptibility
D18Mit49	PCR amplified length variant

Notes

• Experiment
  Disease phenotypes associated with Leishmania major infection were mapped in animals from (CcS-16 x BALB/cHeA)F2 and (CcS-20 x BALB/cHeA)F2 intercross populations. CcS-16 and CcS-20 are recombinant congenic (RC) strains derived from STS/A and BALB/cHeA. Animals were infected with Leishmania major after 9 weeks of age and sacrificed 8 weeks post-infection.
  
  F2 hybrids between BALB/c and CcS20/Dem and F2 hybrids between BALB/c and CcS16 were tested for clinical and immunological consequences post infection. They were genotyped with mircosatellite markers covering the STS-derived segments. Linkage analysis of differing pathological and immunological parameters indicated novel loci and novel functions for previously mapped loci.
  
  In the (BALB/c x CcS16)F2 intercross Lmr28f, mapping with marker D2Mit283, was detected in interaction with Lmr13 (D18Mit49), p=0.0261.
  
  03.23.2016 Curator Note: Lmr13 was originally mapped to D18Mit35 at 24.0 cM on CcS16 using (BALB/c x CcS16)F2 mice in J:82717. The locus identified here, using the same mapping population maps to D18Mit49 at 49.cM but analyzed a different phenotype, we have named the QTL, Lmr29.
  
  Lmr29 (D18Mit49) was detected in interaction with Lmr28f (D2Mit283), p=0.0261. Homozygous STS/S alleles at both loci were associated with low levels of TNF alpha levels in serum. This interaction was attributed with 7.24% of trait variance.