Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  11
• Reference
  J:314541 Parks C, et al., Genetic Modulation of Initial Sensitivity to Delta9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice. Front Genet. 2021;12:659012
• ID
  MGI:7285950

Genes

Gene	Assay Type
Rps6kb1	visible phenotype
Thcir2	visible phenotype

Notes

• Experiment
  Top positional candidate genes include: Ndufs2 (MGI:2385112) for Thcir5; Scp2 (MGI:98254) for Thcir6; Rps6kb1 (MGI:1270849) for Thcir2; Pde4d (MGI:99555) for Thcir4; and Pten (MGI:109583) for Thcir3. These genes are likely to play a role in modulating initial response to THC based on location within modulatory QTL, putative functional sequence variants between B and D haplotypes that segregate among BXD progeny, evidence of genetic control of expression in brain tissue, and previously reported involvement in endocannabinoid/cannabinoid receptor signaling pathways.