Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  14
• Reference
  J:171768 Sinke AP, et al., Genetic analysis of mouse strains with variable serum sodium concentrations identifies the Nalcn sodium channel as a novel player in osmoregulation. Physiol Genomics. 2011 Mar 16;43(5):265-70
• ID
  MGI:7286103

Genes

Gene	Assay Type
Ssc3	visible phenotype
Nalcn	visible phenotype

Notes

• Experiment
  Ssc3 (serum sodium concentration 3, 12 mos, female) maps to Chr 14 and contains only one known gene (Nalcn; MGI:2444306). Within this locus three different haplotypes could be distinguished, which associated with different average serum sodium levels. The association of Nalcn with sodium levels was confirmed by analysis of heterozygous Nalcn knockout mice, which displayed hypernatremia compared with wild-type littermates.