Mapping Data Summary

• Symbol: Tlr4
• Name: toll-like receptor 4
• ID: MGI:96824
• Chromosome: 4

32 mapping experiments

Experiment Type	Details	Chromosome	Reference
CROSS	Cross Type: Backcross	4	J:27675 Bearer EA, et al., Genetic regulation of lipopolysaccharide responses in NZB mice. Exp Clin Immunogenet. 1989;6(3):193-203
CROSS	Cross Type: Backcross	4	J:12085 Coutinho A, et al., Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice. Immunogenetics. 1978 Dec;7(1):17-24
CROSS	Cross Type: Backcross	4	J:6242 O'Brien AD, et al., Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J Immunol. 1980 Jan;124(1):20-4
CROSS	Cross Type: Backcross	4	J:43480 Peiffer-Schneider S, et al., Exclusion of Ifa and Ifb as the Lps gene and mapping of three markers near the Lps locus. Mamm Genome. 1997 Oct;8(10):785-6
CROSS	Cross Type: Backcross	4	J:50273 Poltorak A, et al., Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis. 1998 Sep;24(3):340-55
CROSS	Cross Type: Backcross	4	J:53343 Qureshi ST, et al., Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments]. J Exp Med. 1999 Feb 15;189(4):615-25
CROSS	Cross Type: Backcross	4	J:31350 Qureshi ST, et al., A high-resolution map in the chromosomal region surrounding the Lps locus. Genomics. 1996 Feb 1;31(3):283-94
CROSS	Cross Type: Backcross	4	J:31350 Qureshi ST, et al., A high-resolution map in the chromosomal region surrounding the Lps locus. Genomics. 1996 Feb 1;31(3):283-94
CROSS	Cross Type: Backcross	4	J:5919 Watson J, et al., The genetic mapping of a defective LPS response gene in C3H/HeJ mice. J Immunol. 1978 Feb;120(2):422-4
CROSS	Cross Type: Backcross	4	J:5919 Watson J, et al., The genetic mapping of a defective LPS response gene in C3H/HeJ mice. J Immunol. 1978 Feb;120(2):422-4
CROSS	Cross Type: Backcross	4	J:5938 Watson J, et al., Genetic control of endotoxic responses in mice. J Exp Med. 1978 Jan 1;147(1):39-49
RI	RI/RC Set: BXH	4	J:10087 Fultz MJ, et al., The physical separation of Lps and Ifa loci in BXH recombinant inbred mice. J Immunol. 1989 Nov 1;143(9):3001-6
RI	RI/RC Set: BXH	4	J:5938 Watson J, et al., Genetic control of endotoxic responses in mice. J Exp Med. 1978 Jan 1;147(1):39-49
RI	RI/RC Set: BXH	4	J:5813 Watson J, et al., The response of recombinant inbred strains of mice to bacterial lipopolysaccharides. J Immunol. 1977 Jun;118(6):2088-93
TEXT		4	J:107391 Cook DN, et al., Spontaneous mutations in recombinant inbred mice: mutant toll-like receptor 4 (Tlr4) in BXD29 mice. Genetics. 2006 Mar;172(3):1751-5
TEXT		4	J:51522 Poltorak A, et al., Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998 Dec 11;282(5396):2085-8
TEXT		4	J:13752 Taylor BA, Submaxillary renin activity. Mouse News Lett. 1978;58:49
TEXT		4	J:20449 Vogel SN, et al., Construction of a BALB/c congenic mouse, C.C3H-Lpsd, that expresses the Lpsd allele: analysis of chromosome 4 markers surrounding the Lps gene. Infect Immun. 1994 Oct;62(10):4454-9
TEXT-Genetic Cross		4	J:43480 Peiffer-Schneider S, et al., Exclusion of Ifa and Ifb as the Lps gene and mapping of three markers near the Lps locus. Mamm Genome. 1997 Oct;8(10):785-6
TEXT-Genetic Cross		4	J:50273 Poltorak A, et al., Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis. 1998 Sep;24(3):340-55
TEXT-Genetic Cross		4	J:53343 Qureshi ST, et al., Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments]. J Exp Med. 1999 Feb 15;189(4):615-25
TEXT-Genetic Cross		4	J:54987 Vogel SN, et al., Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J Immunol. 1999 May 15;162(10):5666-70
TEXT-Physical Mapping		4	J:50273 Poltorak A, et al., Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis. 1998 Sep;24(3):340-55
TEXT-Physical Mapping		4	J:53343 Qureshi ST, et al., Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) [see comments]. J Exp Med. 1999 Feb 15;189(4):615-25
TEXT-Physical Mapping		4	J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
TEXT-QTL		4	J:186760 Blanchet C, et al., Mus spretus SEG/Pas mice resist virulent Yersinia pestis, under multigenic control. Genes Immun. 2011 Jan;12(1):23-30
TEXT-QTL		4	J:66468 Kleeberger SR, et al., Genetic susceptibility to ozone-induced lung hyperpermeability: role of toll-like receptor 4. Am J Respir Cell Mol Biol. 2000 May;22(5):620-7
TEXT-QTL		4	J:94346 Korstanje R, et al., Locating Ath8, a locus for murine atherosclerosis susceptibility and testing several of its candidate genes in mice and humans. Atherosclerosis. 2004 Dec;177(2):443-50
TEXT-QTL		4	J:127224 Prows DR, et al., Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice. Physiol Genomics. 2007 Aug 20;30(3):271-81
TEXT-QTL		4	J:244689 Velupillai P, et al., Polymorphisms in toll-like receptor 4 underlie susceptibility to tumor induction by the mouse polyomavirus. J Virol. 2012 Nov;86(21):11541-7
TEXT-QTL		4	J:44625 Wang Y, et al., Host modifier genes affect mouse autoimmunity induced by the lpr gene. Am J Pathol. 1997 Dec;151(6):1791-8
TEXT-Radiation Hybrid		4	J:68900 The Jackson Laboratory Mouse Radiation Hybrid Database, Mouse T31 Radiation Hybrid Data Load. Database Release. 2004;