Hmga2 MGI Mouse Gene Detail - MGI:101761 - high mobility group AT-hook 2

Symbol

Hmga2
Name

high mobility group AT-hook 2
Synonyms

9430083A20Rik, Hmgic, HMGI-C

Feature Type

protein coding gene
IDs

MGI:101761
NCBI Gene: 15364
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr10:120197180-120312374 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 67.94 cM
Mapping Data

12 experiments

SNPs within 2kb

3082 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101761	protein coding gene	Chr10:120197173-120312374 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017775	protein coding gene	Chr10:123633019-123639023 (-)
A/J	MGP_AJ_G0017750	protein coding gene	Chr10:118634716-118752552 (-)
AKR/J	MGP_AKRJ_G0017713	protein coding gene	Chr10:122169858-122293605 (-)
BALB/cJ	MGP_BALBcJ_G0017714	protein coding gene	Chr10:119135408-119141401 (-)
C3H/HeJ	MGP_C3HHeJ_G0017538	protein coding gene	Chr10:122369429-122488624 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018169	protein coding gene	Chr10:127820401-127827666 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015850	protein coding gene	Chr10:113095295-113101519 (-)
CAST/EiJ	MGP_CASTEiJ_G0017098	protein coding gene	Chr10:122812719-122820607 (-)
CBA/J	MGP_CBAJ_G0017507	protein coding gene	Chr10:132912031-133051502 (-)
DBA/2J	MGP_DBA2J_G0017613	protein coding gene	Chr10:117878956-117884949 (-)
FVB/NJ	MGP_FVBNJ_G0017608	protein coding gene	Chr10:116753990-116868631 (-)
LP/J	MGP_LPJ_G0017687	protein coding gene	Chr10:124070280-124193920 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017637	protein coding gene	Chr10:135631969-135637962 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018209	protein coding gene	Chr10:122285859-122291861 (-)
PWK/PhJ	MGP_PWKPhJ_G0016883	protein coding gene	Chr10:117978750-117985051 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016674	protein coding gene	Chr10:121067816-121190487 (-)
WSB/EiJ	MGP_WSBEiJ_G0017159	protein coding gene	Chr10:122417201-122541769 (-)

Human Ortholog

HMGA2, high mobility group AT-hook 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HMGA2, high mobility group AT-hook 2
Synonyms

BABL, HMGI-C, HMGIC, LIPO, SRS5, STQTL9
Links

HGNC:5009

NCBI Gene ID: 8091

neXtProt AC: NX_P52926

UniProt: P52926
Chr Location

12q14.3; chr12:65824460-65966291 (+) GRCh38

MGI Vertebrate Homology

Hmga2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HMGA2
Gene Tree

Hmga2

Diseases

4 with human HMGA2 associations

				Human Disease	Mouse Models
				leiomyoma IDs leiomyoma DOID:127 MESH:D007889 NCI:C3157 UMLS_CUI:C0023267
				lipoma IDs lipoma DOID:3315 DOID:3154 DOID:9291 ICD10CM:D17 ICD10CM:D17.9 ICD9CM:214 ICD9CM:214.9 MESH:D008067 MESH:D018205 NCI:C3192 NCI:C4248 NCI:C4502 UMLS_CUI:C0023798 UMLS_CUI:C0206631 UMLS_CUI:C0346118
				ovarian cancer IDs ovarian cancer DOID:2394 DOID:0060070 DOID:2144 DOID:9595 ICD10CM:C56 ICD9CM:183.0 MESH:D010051 NCI:C4984 NCI:C7431 OMIM:167000 OMIM:607893 ORDO:213500 ORDO:213517 UMLS_CUI:C0919267 UMLS_CUI:C1140680 UMLS_CUI:C1299247
				Silver-Russell syndrome IDs Silver-Russell syndrome DOID:14681 ICD10CM:Q87.19 MESH:D056730 NCI:C85068 OMIM:180860 UMLS_CUI:C0175693

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

51 phenotypes from 4 alleles in 5 genetic backgrounds
12 phenotypes from multigenic genotypes
2 images
45 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Spontaneous

1
Targeted

3
Transgenic

2
Genomic Mutations

2 involving Hmga2
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for null mutations exhibit proportionate dwarfing with a significant reduction in body weight, reduced amounts of fat tissue, and infertility in both sexes. Mutants have normal growth hormone levels.

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All GO Annotations

133
GO References

25

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1485
Tissues

389
cDNA Data

149
Literature Summary

53

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA HMGA2

Xenbase hmga2

ZFIN hmga2

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All Sequences

51
RefSeq

4
UniProt

2
CCDS

CCDS36073.1, CCDS83758.1

Ensembl

ENSMUSG00000056758 (Evidence)
NCBI Gene

15364

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056758	Ensembl Gene Model \| MGI Sequence Detail	115195	C57BL/6J	± kb
transcript	ENSMUST00000159699	Ensembl \| MGI Sequence Detail	3810	Not Applicable
polypeptide	ENSMUSP00000123998	Ensembl \| MGI Sequence Detail	129	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008629 high mobility group protein HMGI-C

(term hierarchy)
InterPro Domains

IPR017956 AT hook, DNA-binding motif

IPR000116 High mobility group protein HMGA
GlyGen

P52927 1 site, 1 O-linked glycan (1 site)

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All nucleic 181

Genomic 13

cDNA 149

Primer pair 9

Other 10

Microarray probesets 6

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MGD-MRK-13252, MGD-MRK-18567, MGI:1924607

Summaries

All 150

Developmental Gene Expression 53

Diseases 1

Gene Ontology 25

Phenotypes 45
Earliest

J:25351 Macarthur JW, Genetics of body size and related characters. Am Naturalist. 1944;78:142-57
Latest

J:353625 Zhu Y, et al., HDAC1 and HDAC2 orchestrate Wnt signaling to regulate neural progenitor transition during brain development. iScience. 2024 Sep 20;27(9):110600

TSS for Hmga2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99580	Chr10:120312850-120312927 (-)	-515 bp
Tssr99579	Chr10:120312823-120312841 (-)	-458 bp
Tssr99578	Chr10:120312803-120312821 (-)	-438 bp
Tssr99577	Chr10:120312688-120312718 (-)	-329 bp
Tssr99576	Chr10:120312641-120312669 (-)	-281 bp
Tssr99575	Chr10:120312615-120312628 (-)	-248 bp
Tssr99574	Chr10:120312395-120312432 (-)	-40 bp
Tssr99573	Chr10:120312377-120312388 (-)	-9 bp
Tssr99572	Chr10:120312216-120312225 (-)	153 bp
Tssr99571	Chr10:120312159-120312215 (-)	187 bp
Tssr99570	Chr10:120312150-120312151 (-)	223 bp
Tssr99569	Chr10:120312127-120312147 (-)	237 bp
Tssr99568	Chr10:120312115-120312126 (-)	253 bp
Tssr3376	Chr10:120298800-120298809 (-)	13,569 bp
Tssr99567	Chr10:120244227-120244232 (-)	68,144 bp
Tssr99566	Chr10:120206103-120206106 (-)	106,269 bp
Tssr99565	Chr10:120199637-120199650 (-)	112,730 bp
Tssr99564	Chr10:120198571-120198574 (-)	113,801 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24