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Sntb2 Gene Detail
Summary
  • Symbol
    Sntb2
  • Name
    syntrophin, basic 2
  • Synonyms
    Snt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101771
    NCBI Gene: 20650
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:107662372-107740864 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.38 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1755 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101771
 protein coding gene Chr8:107662372-107746346 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034091
 protein coding gene Chr8:109329804-109419417 (+)
A/J MGP_AJ_G0034071
 protein coding gene Chr8:104957350-105037816 (+)
AKR/J MGP_AKRJ_G0033997
 protein coding gene Chr8:108016381-108100953 (+)
BALB/cJ MGP_BALBcJ_G0034064
 protein coding gene Chr8:105147889-105231861 (+)
C3H/HeJ MGP_C3HHeJ_G0033776
 protein coding gene Chr8:108738481-108824860 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034584
 protein coding gene Chr8:113334660-113419072 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031526
 protein coding gene Chr8:98065281-98144913 (+)
CAST/EiJ MGP_CASTEiJ_G0033102
 protein coding gene Chr8:108258982-108349801 (+)
CBA/J MGP_CBAJ_G0033749
 protein coding gene Chr8:116998178-117094195 (+)
DBA/2J MGP_DBA2J_G0033904
 protein coding gene Chr8:104285959-104366141 (+)
FVB/NJ MGP_FVBNJ_G0033849
 protein coding gene Chr8:103222124-103300534 (+)
LP/J MGP_LPJ_G0033995
 protein coding gene Chr8:109519868-109603436 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033893
 protein coding gene Chr8:120125536-120212780 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034602
 protein coding gene Chr8:107943832-108030131 (+)
PWK/PhJ MGP_PWKPhJ_G0032804
 protein coding gene Chr8:103703705-103789077 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032644
 protein coding gene Chr8:106660102-106742543 (+)
WSB/EiJ MGP_WSBEiJ_G0033218
 protein coding gene Chr8:108656696-108747847 (+)



Homology
more
  • Human Ortholog
    SNTB2, syntrophin beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SNTB2, syntrophin beta 2
  • Synonyms
    D16S2531E, EST25263, SNT2B2, SNT3, SNTL
  • Links
    NCBI Gene ID: 6645
    neXtProt AC: NX_Q13425
    UniProt: Q13425

  • Chr Location
    16q22.1; chr16:69187147-69309052 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    15 phenotype references
Homozygous null mice have no overt phenotype. They are fertile and motile with no signs of muscular dystrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    11
  • cDNA Data
    50
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20650 NCBI Gene Model | MGI Sequence Detail 78493 C57BL/6J ±  kb
transcript NM_009229 RefSeq | MGI Sequence Detail 4473 ZRU/MplStud  
polypeptide Q61235 UniProt | EBI | MGI Sequence Detail 520 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 54
    Genomic 3
    cDNA 50
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-14480, MGD-MRK-18578
References
more
  • Summaries
    All 59
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 15
  • Earliest
    J:20636 Adams ME, et al., Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution. Neuron. 1993 Sep;11(3):531-40
  • Latest
    J:344589 Rein-Fischboeck L, et al., Lower adiposity does not protect beta-2 syntrophin null mice from hepatic steatosis and inflammation in experimental non-alcoholic steatohepatitis. Gene. 2023 Jan 18;859:147209
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory