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Cd86 Gene Detail
Summary
  • Symbol
    Cd86
  • Name
    CD86 antigen
  • Synonyms
    B70, B7-2, B7.2, Cd28l2, Ly-58, Ly58, MB7-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101773
    NCBI Gene: 12524
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36424231-36486443 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 25.72 cM, cytoband B5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1239 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101773
 protein coding gene Chr16:36389318-36486443 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022790
 protein coding gene Chr16:35003577-35065861 (-)
A/J MGP_AJ_G0022755
 protein coding gene Chr16:33284806-33349255 (-)
AKR/J MGP_AKRJ_G0022727
 protein coding gene Chr16:34549657-34622733 (-)
BALB/cJ MGP_BALBcJ_G0022756
 protein coding gene Chr16:33389223-33451567 (-)
C3H/HeJ MGP_C3HHeJ_G0022520
 protein coding gene Chr16:34673317-34735882 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023203
 protein coding gene Chr16:35835257-35899839 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020717
 protein coding gene Chr16:33656481-33714930 (-)
CAST/EiJ MGP_CASTEiJ_G0022046
 protein coding gene Chr16:34785359-34853206 (-)
CBA/J MGP_CBAJ_G0022491
 protein coding gene Chr16:37409911-37475966 (-)
DBA/2J MGP_DBA2J_G0022623
 protein coding gene Chr16:33176594-33240191 (-)
FVB/NJ MGP_FVBNJ_G0022598
 protein coding gene Chr16:33208959-33271245 (-)
LP/J MGP_LPJ_G0022691
 protein coding gene Chr16:34720587-34785281 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022617
 protein coding gene Chr16:36450606-36518207 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023218
 protein coding gene Chr16:34504749-34566374 (-)
PWK/PhJ MGP_PWKPhJ_G0021786
 protein coding gene Chr16:33571434-33632793 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021617
 protein coding gene Chr16:34426233-34486088 (-)
WSB/EiJ MGP_WSBEiJ_G0022090
 protein coding gene Chr16:34555048-34622823 (-)



Homology
more
  • Human Ortholog
    CD86, CD86 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD86, CD86 molecule
  • Synonyms
    B70, B7-2, B7.2, CD28LG2, LAB72
  • Links
    NCBI Gene ID: 942
    neXtProt AC: NX_P42081
    UniProt: P42081

  • Chr Location
    3q13.33; chr3:122055362-122121139 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cd86 mouse models; 8 with human CD86 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 5 alleles in 7 genetic backgrounds
    37 phenotypes from multigenic genotypes
    193 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice on an NOD background display a phenotype similar to human Guillain-Barre Syndrome, exhibiting severe peripheral nervous system inflammation, sciatic nerve demyelination, elevated auto-antibodies to myelin protein zero, hindlimb paralysis, and weak forelimb grip.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    775
  • Tissues
    46
  • cDNA Data
    30
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022901 Ensembl Gene Model | MGI Sequence Detail 62213 C57BL/6J ±  kb
    transcript ENSMUST00000089620 Ensembl | MGI Sequence Detail 2539 Not Applicable  
    polypeptide ENSMUSP00000087047 Ensembl | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 17
      cDNA 31
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12000, MGD-MRK-12043, MGD-MRK-18572, MGD-MRK-18580
    References
    more
    • Summaries
      All 306
      Developmental Gene Expression 7
      Diseases 3
      Gene Ontology 16
      Phenotypes 193
    • Earliest
      J:7166 Gibson DM, et al., Recombination between kappa chain genetic markers and the Lyt-3 locus. Immunogenetics. 1983;18(2):111-6
    • Latest
      J:352898 Jeon J, et al., Deciphering perivascular macrophages and microglia in the retinal ganglion cell layers. Front Cell Dev Biol. 2024;12:1368021
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory