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Cd80 Gene Detail
Summary
  • Symbol
    Cd80
  • Name
    CD80 antigen
  • Synonyms
    B7-1, B7.1, Cd28l, Ly-53, Ly53
  • Feature Type
    protein coding gene
  • IDs
    MGI:101775
    NCBI Gene: 12519
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38277793-38316682 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.86 cM, cytoband B5
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1044 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101775
 protein coding gene Chr16:38275923-38316697 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022816
 protein coding gene Chr16:36988893-37017867 (+)
A/J MGP_AJ_G0022781
 protein coding gene Chr16:35151040-35178982 (+)
AKR/J MGP_AKRJ_G0022753
 protein coding gene Chr16:36487257-36519572 (+)
BALB/cJ MGP_BALBcJ_G0022782
 protein coding gene Chr16:35273667-35303475 (+)
C3H/HeJ MGP_C3HHeJ_G0022546
 protein coding gene Chr16:36591618-36624344 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023229
 protein coding gene Chr16:37830924-37862217 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020744
 protein coding gene Chr16:35527527-35556082 (+)
CAST/EiJ MGP_CASTEiJ_G0022072
 protein coding gene Chr16:36746132-36779157 (+)
CBA/J MGP_CBAJ_G0022517
 protein coding gene Chr16:39489803-39519236 (+)
DBA/2J MGP_DBA2J_G0022649
 protein coding gene Chr16:35036377-35064347 (+)
FVB/NJ MGP_FVBNJ_G0022624
 protein coding gene Chr16:35066603-35094736 (+)
LP/J MGP_LPJ_G0022717
 protein coding gene Chr16:36668141-36698144 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022643
 protein coding gene Chr16:38604814-38634739 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023244
 protein coding gene Chr16:36450759-36482018 (+)
PWK/PhJ MGP_PWKPhJ_G0021812
 protein coding gene Chr16:35451050-35480084 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021643
 protein coding gene Chr16:36344806-36374244 (+)
WSB/EiJ MGP_WSBEiJ_G0022116
 protein coding gene Chr16:36521413-36550767 (+)



Homology
more
  • Human Ortholog
    CD80, CD80 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD80, CD80 molecule
  • Synonyms
    B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
  • Links
    NCBI Gene ID: 941
    neXtProt AC: NX_P33681
    UniProt: P33681

  • Chr Location
    3q13.33; chr3:119524293-119559614 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD80 associations

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 7 genetic backgrounds
    35 phenotypes from multigenic genotypes
    171 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a 70% reduction in the mixed lymphocyte response in LPS- and dextran sulfate-stimulated B cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    2
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12519 NCBI Gene Model | MGI Sequence Detail 38890 C57BL/6J ±  kb
    transcript NM_001359898 RefSeq | MGI Sequence Detail 2688 ZRU/MplStud  
    polypeptide Q00609 UniProt | EBI | MGI Sequence Detail 306 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 12
      cDNA 22

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11996, MGD-MRK-12039, MGD-MRK-1846, MGD-MRK-18582
    References
    more
    • Summaries
      All 318
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 17
      Phenotypes 171
    • Earliest
      J:10835 Kubota H, et al., Identification and gene cloning of a new phosphatidylinositol-linked antigen expressed on mature lymphocytes. Down-regulation by lymphocyte activation. J Immunol. 1990 Dec 1;145(11):3924-31
    • Latest
      J:343278 Subileau M, et al., Ontogenesis of the Mouse Ocular Surface Lymphatic Vascular Network. Invest Ophthalmol Vis Sci. 2023 Dec 1;64(15):7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory