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Lhx4 Gene Detail
Summary
  • Symbol
    Lhx4
  • Name
    LIM homeobox protein 4
  • Synonyms
    A330062J17Rik, Gsh-4, Gsh4
  • Feature Type
    protein coding gene
  • IDs
    MGI:101776
    NCBI Gene: 16872
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:155573777-155627430 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 67.47 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1364 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101776
 protein coding gene Chr1:155573777-155627481 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016615
 protein coding gene Chr1:160635348-160690083 (-)
A/J MGP_AJ_G0016596
 protein coding gene Chr1:154187292-154241160 (-)
AKR/J MGP_AKRJ_G0016562
 protein coding gene Chr1:158923557-158977379 (-)
BALB/cJ MGP_BALBcJ_G0016557
 protein coding gene Chr1:154695006-154749072 (-)
C3H/HeJ MGP_C3HHeJ_G0016381
 protein coding gene Chr1:159048580-159104703 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017018
 protein coding gene Chr1:166154831-166209449 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014727
 protein coding gene Chr1:146414488-146469387 (-)
CAST/EiJ MGP_CASTEiJ_G0015961
 protein coding gene Chr1:158575334-158638216 (-)
CBA/J MGP_CBAJ_G0016356
 protein coding gene Chr1:171997720-172058300 (-)
DBA/2J MGP_DBA2J_G0016462
 protein coding gene Chr1:153156998-153214342 (-)
FVB/NJ MGP_FVBNJ_G0016460
 protein coding gene Chr1:151624418-151680157 (-)
LP/J MGP_LPJ_G0016533
 protein coding gene Chr1:161782013-161838055 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016485
 protein coding gene Chr1:179589626-179648417 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017054
 protein coding gene Chr1:158728435-158783304 (-)
PWK/PhJ MGP_PWKPhJ_G0015747
 protein coding gene Chr1:152231493-152285588 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015534
 protein coding gene Chr1:157468524-157521905 (-)
WSB/EiJ MGP_WSBEiJ_G0016023
 protein coding gene Chr1:158810095-158866867 (-)



Homology
more
  • Human Ortholog
    LHX4, LIM homeobox 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LHX4, LIM homeobox 4
  • Synonyms
    CPHD4
  • Links
    NCBI Gene ID: 89884
    neXtProt AC: NX_Q969G2
    UniProt: Q969G2

  • Chr Location
    1q25.2; chr1:180228375-180278984 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LHX4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    13 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in abnormal lung development and neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1114
  • Tissues
    283
  • cDNA Data
    15
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026468 Ensembl Gene Model | MGI Sequence Detail 53654 C57BL/6J ±  kb
    transcript ENSMUST00000027740 Ensembl | MGI Sequence Detail 5514 Not Applicable  
    polypeptide ENSMUSP00000027740 Ensembl | MGI Sequence Detail 390 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 17
      Primer pair 1
      Other 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10287, MGD-MRK-10292, MGD-MRK-18583, MGI:3624428
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 36
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
    • Latest
      J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory