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Mybl2 Gene Detail
Summary
  • Symbol
    Mybl2
  • Name
    myeloblastosis oncogene-like 2
  • Synonyms
    Bmyb, B-Myb
  • Feature Type
    protein coding gene
  • IDs
    MGI:101785
    NCBI Gene: 17865
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:162896607-162926608 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    998 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101785
 protein coding gene Chr2:162896246-162926608 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026817
 protein coding gene Chr2:168348784-168388303 (+)
A/J MGP_AJ_G0026783
 protein coding gene Chr2:161593462-161623789 (+)
AKR/J MGP_AKRJ_G0026754
 protein coding gene Chr2:166356263-166398293 (+)
BALB/cJ MGP_BALBcJ_G0026792
 protein coding gene Chr2:161909438-161949370 (+)
C3H/HeJ MGP_C3HHeJ_G0026534
 protein coding gene Chr2:166708213-166741171 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027240
 protein coding gene Chr2:173291980-173325384 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024610
 protein coding gene Chr2:154883001-154913540 (+)
CAST/EiJ MGP_CASTEiJ_G0025995
 protein coding gene Chr2:167078646-167113890 (+)
CBA/J MGP_CBAJ_G0026511
 protein coding gene Chr2:179558179-179606941 (+)
DBA/2J MGP_DBA2J_G0026649
 protein coding gene Chr2:160761789-160792860 (+)
FVB/NJ MGP_FVBNJ_G0026615
 protein coding gene Chr2:159126986-159163910 (+)
LP/J MGP_LPJ_G0026752
 protein coding gene Chr2:168490991-168532729 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026637
 protein coding gene Chr2:183239006-183276748 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027296
 protein coding gene Chr2:166245787-166281129 (+)
PWK/PhJ MGP_PWKPhJ_G0025729
 protein coding gene Chr2:160307883-160344756 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025532
 protein coding gene Chr2:165105062-165142289 (+)
WSB/EiJ MGP_WSBEiJ_G0026065
 protein coding gene Chr2:167106868-167140550 (+)



Homology
more
  • Human Ortholog
    MYBL2, MYB proto-oncogene like 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYBL2, MYB proto-oncogene like 2
  • Synonyms
    B-MYB, BMYB
  • Links
    NCBI Gene ID: 4605
    neXtProt AC: NX_P10244
    UniProt: P10244

  • Chr Location
    20q13.12; chr20:43667019-43716495 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Mybl2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 5 alleles in 8 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos shortly after implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1100
  • Tissues
    125
  • cDNA Data
    113
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017861 Ensembl Gene Model | MGI Sequence Detail 30002 C57BL/6J ±  kb
    transcript ENSMUST00000018005 Ensembl | MGI Sequence Detail 3651 Not Applicable  
    polypeptide ENSMUSP00000018005 Ensembl | MGI Sequence Detail 704 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      cDNA 115
      Primer pair 3

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-18593
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 23
      Diseases 1
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:2269 Lam EW, et al., Characterization and cell cycle-regulated expression of mouse B-myb. Oncogene. 1992 Sep;7(9):1885-90
    • Latest
      J:354288 Young CA, et al., A cochlear progenitor pool influences patterning of the mammalian sensory epithelium via MYBL2. Development. 2024 Sep 1;151(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory