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F2r Gene Detail
Summary
  • Symbol
    F2r
  • Name
    coagulation factor II thrombin receptor
  • Synonyms
    Cf2r, Par1, protease-activated receptor 1, thrombin receptor, ThrR
  • Feature Type
    protein coding gene
  • IDs
    MGI:101802
    NCBI Gene: 14062
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:95738311-95754995 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 50.21 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    536 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101802
 protein coding gene Chr13:95738288-95754995 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020843
 protein coding gene Chr13:97083963-97102299 (-)
A/J MGP_AJ_G0020797
 protein coding gene Chr13:93438226-93454844 (-)
AKR/J MGP_AKRJ_G0020771
 protein coding gene Chr13:96291686-96312595 (-)
BALB/cJ MGP_BALBcJ_G0020794
 protein coding gene Chr13:94117253-94134268 (-)
C3H/HeJ MGP_C3HHeJ_G0020587
 protein coding gene Chr13:95983278-95999853 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021230
 protein coding gene Chr13:100026630-100044642 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018799
 protein coding gene Chr13:89269321-89286146 (-)
CAST/EiJ MGP_CASTEiJ_G0020106
 protein coding gene Chr13:95290286-95307643 (-)
CBA/J MGP_CBAJ_G0020546
 protein coding gene Chr13:104000280-104020028 (-)
DBA/2J MGP_DBA2J_G0020671
 protein coding gene Chr13:93216348-93232980 (-)
FVB/NJ MGP_FVBNJ_G0020652
 protein coding gene Chr13:92001524-92018129 (-)
LP/J MGP_LPJ_G0020746
 protein coding gene Chr13:97194002-97212502 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020680
 protein coding gene Chr13:104434877-104451547 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021270
 protein coding gene Chr13:95694479-95712148 (-)
PWK/PhJ MGP_PWKPhJ_G0019858
 protein coding gene Chr13:92000122-92017032 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019682
 protein coding gene Chr13:91986269-92004477 (-)
WSB/EiJ MGP_WSBEiJ_G0020163
 protein coding gene Chr13:96197213-96215246 (-)



Homology
more
  • Human Ortholog
    F2R, coagulation factor II thrombin receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    F2R, coagulation factor II thrombin receptor
  • Synonyms
    CF2R, HTR, PAR-1, PAR1, TR
  • Links
    NCBI Gene ID: 2149
    neXtProt AC: NX_P25116
    UniProt: P25116

  • Chr Location
    5q13.3; chr5:76716126-76735770 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 4 alleles in 8 genetic backgrounds
    21 phenotypes from multigenic genotypes
    120 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutations of this locus result in increased midgestational lethality, with up to ~50% of mutants surviving to adulthood. Gene deficiency does not affect thrombin signaling in mouse platelets but markedly attenuates thrombin signaling in mouse microvascular endothelial cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    100
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    951
  • Tissues
    140
  • cDNA Data
    11
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048376 Ensembl Gene Model | MGI Sequence Detail 16685 C57BL/6J ±  kb
    transcript ENSMUST00000059193 Ensembl | MGI Sequence Detail 3336 Not Applicable  
    polypeptide ENSMUSP00000061754 Ensembl | MGI Sequence Detail 430 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 4
      cDNA 11
      Primer pair 6
      Other 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-18613, MGI:2145260
    References
    more
    • Summaries
      All 199
      Developmental Gene Expression 16
      Gene Ontology 11
      Phenotypes 120
    • Earliest
      J:16414 Soifer SJ, et al., Disparate temporal expression of the prothrombin and thrombin receptor genes during mouse development. Am J Pathol. 1994 Jan;144(1):60-9
    • Latest
      J:358192 Zoungrana LI, et al., Activated protein C signaling mediates neuroinflammation in seizure induced by pilocarpine. Biochem Biophys Rep. 2023 Sep;35:101550
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory