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Elk1 Gene Detail
Summary
  • Symbol
    Elk1
  • Name
    ELK1, member of ETS oncogene family
  • Synonyms
    Elk-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101833
    NCBI Gene: 13712
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:20799634-20816847 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 16.45 cM, cytoband A1-A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101833
 protein coding gene ChrX:20799634-20816847 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035601
 protein coding gene ChrX:15836607-15853820 (-)
A/J MGP_AJ_G0035578
 protein coding gene ChrX:15916334-15933535 (-)
AKR/J MGP_AKRJ_G0035511
 protein coding gene ChrX:16469402-16486665 (-)
BALB/cJ MGP_BALBcJ_G0035571
 protein coding gene ChrX:15685409-15702622 (-)
C3H/HeJ MGP_C3HHeJ_G0035289
 protein coding gene ChrX:16053932-16071145 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036107
 protein coding gene ChrX:16255737-16272950 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032971
 protein coding gene ChrX:14172469-14189392 (-)
CAST/EiJ MGP_CASTEiJ_G0034580
 protein coding gene ChrX:15350926-15368117 (-)
CBA/J MGP_CBAJ_G0035258
 protein coding gene ChrX:16994390-17011801 (-)
DBA/2J MGP_DBA2J_G0035410
 protein coding gene ChrX:15718941-15737008 (-)
FVB/NJ MGP_FVBNJ_G0035356
 protein coding gene ChrX:15627820-15645233 (-)
LP/J MGP_LPJ_G0035492
 protein coding gene ChrX:16089596-16106809 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035400
 protein coding gene ChrX:17256402-17273519 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036114
 protein coding gene ChrX:15754048-15771208 (-)
PWK/PhJ MGP_PWKPhJ_G0034281
 protein coding gene ChrX:14925110-14936175 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034121
 protein coding gene ChrX:15763139-15780919 (-)
WSB/EiJ MGP_WSBEiJ_G0034715
 protein coding gene ChrX:15621092-15638386 (-)



Homology
more
  • Human Ortholog
    ELK1, ETS transcription factor ELK1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELK1, ETS transcription factor ELK1
  • Links
    NCBI Gene ID: 2002
    neXtProt AC: NX_P19419
    UniProt: P19419

  • Chr Location
    Xp11.23; chrX:47635520-47650604 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene causes no apparent phenotype. Hemizygous males carrying the HygTk gene of a null allele are sterile, likely due to aberrant expression of the Tk gene in the testis; phenotypic correction is obtained with a second null allele that does not contain the Tk gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    938
  • Tissues
    190
  • cDNA Data
    17
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13712 NCBI Gene Model | MGI Sequence Detail 17214 C57BL/6J ±  kb
    transcript NM_007922 RefSeq | MGI Sequence Detail 3548 Not Specified  
    polypeptide P41969 UniProt | EBI | MGI Sequence Detail 429 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 2
      cDNA 18
      Primer pair 2
      Other 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-18654
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 18
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:19206 Giovane A, et al., Net, a new ets transcription factor that is activated by Ras. Genes Dev. 1994 Jul 1;8(13):1502-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory