Traf1 MGI Mouse Gene Detail - MGI:101836 - TNF receptor-associated factor 1

Symbol

Traf1
Name

TNF receptor-associated factor 1
Synonyms

4732496E14Rik

Feature Type

protein coding gene
IDs

MGI:101836
NCBI Gene: 22029
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr2:34831762-34851784 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 23.13 cM
Mapping Data

2 experiments

SNPs within 2kb

575 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101836	protein coding gene	Chr2:34831762-34851784 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025646	protein coding gene	Chr2:33553057-33573073 (-)
A/J	MGP_AJ_G0025623	protein coding gene	Chr2:32131763-32152237 (-)
AKR/J	MGP_AKRJ_G0025593	protein coding gene	Chr2:33267222-33287207 (-)
BALB/cJ	MGP_BALBcJ_G0025620	protein coding gene	Chr2:32240337-32261315 (-)
C3H/HeJ	MGP_C3HHeJ_G0025380	protein coding gene	Chr2:33160767-33180350 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026064	protein coding gene	Chr2:34528403-34549191 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023473	protein coding gene	Chr2:30822211-30840797 (-)
CAST/EiJ	MGP_CASTEiJ_G0024842	protein coding gene	Chr2:33145031-33165082 (-)
CBA/J	MGP_CBAJ_G0025358	protein coding gene	Chr2:35861209-35882655 (-)
DBA/2J	MGP_DBA2J_G0025491	protein coding gene	Chr2:31899913-31920135 (-)
FVB/NJ	MGP_FVBNJ_G0025453	protein coding gene	Chr2:31800361-31820250 (-)
LP/J	MGP_LPJ_G0025577	protein coding gene	Chr2:33482981-33503051 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025484	protein coding gene	Chr2:35381268-35407428 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026122	protein coding gene	Chr2:33151913-33173543 (-)
PWK/PhJ	MGP_PWKPhJ_G0024590	protein coding gene	Chr2:31811379-31832221 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024390	protein coding gene	Chr2:33316930-33340612 (-)
WSB/EiJ	MGP_WSBEiJ_G0024911	protein coding gene	Chr2:33333010-33352963 (-)

Human Ortholog

TRAF1, TNF receptor associated factor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRAF1, TNF receptor associated factor 1
Synonyms

EBI6, MGC:10353
Links

HGNC:12031

NCBI Gene ID: 7185

neXtProt AC: NX_Q13077

UniProt: Q13077
Chr Location

9q33.2; chr9:120902393-120929173 (-) GRCh38

MGI Vertebrate Homology

Traf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRAF1
Protein SuperFamily

TRAF
Gene Tree

Traf1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

4
Gene trapped

5
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit abnormal T cell functionality.

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All GO Annotations

28
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

805
Tissues

46
cDNA Data

22
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

68
RefSeq

18
UniProt

5
CCDS

CCDS15956.1

Ensembl

ENSMUSG00000026875 (Evidence)
NCBI Gene

22029

			Length	Strain/Species	Flank
genomic	22029	NCBI Gene Model \| MGI Sequence Detail	20023	C57BL/6J	± kb
transcript	NM_009421	RefSeq \| MGI Sequence Detail	3833	C57BL/6
polypeptide	P39428	UniProt \| EBI \| MGI Sequence Detail	409	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000002287 TNF receptor-associated factor 1

(term hierarchy)
InterPro Domains

IPR002083 MATH/TRAF domain

IPR037306 TNF receptor-associated factor 1, MATH domain

IPR032070 TNF receptor-associated factor, BIRC3 binding domain

IPR012227 TNF receptor-associated factor TRAF, metazoa

IPR049342 TRAF1-6/MEP1A/B-like, MATH domain

IPR008974 TRAF-like

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All nucleic 26

Genomic 1

cDNA 22

Primer pair 1

Other 2

Microarray probesets 4

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MGD-MRK-18657, MGI:2443877

Summaries

All 76

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 30
Earliest

J:19898 Rothe M, et al., A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell. 1994 Aug 26;78(4):681-92
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Traf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr23681	Chr2:34853756-34853763 (-)	-1,976 bp
Tssr23680	Chr2:34852993-34853003 (-)	-1,214 bp
Tssr23679	Chr2:34852939-34852966 (-)	-1,169 bp
Tssr23678	Chr2:34851965-34851981 (-)	-189 bp
Tssr23677	Chr2:34851832-34851850 (-)	-57 bp
Tssr23676	Chr2:34851814-34851830 (-)	-38 bp
Tssr23675	Chr2:34851801-34851808 (-)	-21 bp
Tssr23674	Chr2:34851763-34851800 (-)	2 bp
Tssr23673	Chr2:34851567-34851651 (-)	175 bp
Tssr23672	Chr2:34848724-34848755 (-)	3,044 bp
Tssr23671	Chr2:34848619-34848644 (-)	3,152 bp
Tssr23670	Chr2:34848164-34848185 (-)	3,609 bp
Tssr23669	Chr2:34848141-34848153 (-)	3,637 bp
Tssr23668	Chr2:34848114-34848125 (-)	3,664 bp
Tssr23667	Chr2:34848090-34848100 (-)	3,689 bp
Tssr23666	Chr2:34843489-34843519 (-)	8,280 bp
Tssr23665	Chr2:34834520-34834542 (-)	17,253 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24