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Usp45 Gene Detail
Summary
  • Symbol
    Usp45
  • Name
    ubiquitin specific petidase 45
  • Synonyms
    3110003C05Rik, 4930550B20Rik, Gcap7
  • Feature Type
    protein coding gene
  • IDs
    MGI:101850
    NCBI Gene: 77593
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:21767161-21837872 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 8.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2259 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101850
 protein coding gene Chr4:21767156-21837872 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028092
 protein coding gene Chr4:18786546-18859881 (+)
A/J MGP_AJ_G0028050
 protein coding gene Chr4:18224221-18300555 (+)
AKR/J MGP_AKRJ_G0028015
 protein coding gene Chr4:18644412-18721291 (+)
BALB/cJ MGP_BALBcJ_G0028061
 protein coding gene Chr4:18284114-18356545 (+)
C3H/HeJ MGP_C3HHeJ_G0027791
 protein coding gene Chr4:18813804-18889712 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028504
 protein coding gene Chr4:19548244-19624457 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025846
 protein coding gene Chr4:16884385-16964641 (+)
CAST/EiJ MGP_CASTEiJ_G0027246
 protein coding gene Chr4:18576929-18660353 (+)
CBA/J MGP_CBAJ_G0027764
 protein coding gene Chr4:20112192-20190779 (+)
DBA/2J MGP_DBA2J_G0027907
 protein coding gene Chr4:18094758-18172574 (+)
FVB/NJ MGP_FVBNJ_G0027873
 protein coding gene Chr4:17807336-17878616 (+)
LP/J MGP_LPJ_G0028016
 protein coding gene Chr4:18858840-18935910 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027906
 protein coding gene Chr4:21341453-21418413 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028563
 protein coding gene Chr4:18591193-18678868 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026795
 protein coding gene Chr4:18420198-18488739 (+)
WSB/EiJ MGP_WSBEiJ_G0027323
 protein coding gene Chr4:18595988-18668751 (+)



Homology
more
  • Human Ortholog
    USP45, ubiquitin specific peptidase 45
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP45, ubiquitin specific peptidase 45
  • Synonyms
    LCA19
  • Links
    NCBI Gene ID: 85015
    neXtProt AC: NX_Q70EL2
    UniProt: Q70EL2

  • Chr Location
    6q16.2; chr6:99432325-99521728 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Usp45 mouse models; 1 with human USP45 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit reduced scotopic and photopic responses and fewer cones
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    55
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 77593 NCBI Gene Model | MGI Sequence Detail 70712 C57BL/6J ±  kb
transcript NM_152825 RefSeq | MGI Sequence Detail 6018 C57BL/6  
polypeptide Q8K387 UniProt | EBI | MGI Sequence Detail 813 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    cDNA 55

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-18673, MGI:1920359, MGI:1924843, MGI:2140372
References
more
  • Summaries
    All 38
    Diseases 1
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:19885 Kambouris M, et al., Novel cDNA clones obtained by antibody screening of a mouse cerebellar cDNA expression library. Brain Res Mol Brain Res. 1994 Sep;25(3-4):183-91
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory