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Pou3f4 Gene Detail
Summary
  • Symbol
    Pou3f4
  • Name
    POU domain, class 3, transcription factor 4
  • Synonyms
    Brn4, BRN-4, Otf9
  • Feature Type
    protein coding gene
  • IDs
    MGI:101894
    NCBI Gene: 18994
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:109857886-109860813 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 48.20 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101894
 protein coding gene ChrX:109857886-109862714 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036024
 protein coding gene ChrX:107689956-107692883 (+)
A/J MGP_AJ_G0036004
 protein coding gene ChrX:107585332-107588243 (+)
AKR/J MGP_AKRJ_G0035923
 protein coding gene ChrX:110892794-110895721 (+)
BALB/cJ MGP_BALBcJ_G0035995
 protein coding gene ChrX:106200585-106203511 (+)
C3H/HeJ MGP_C3HHeJ_G0035701
 protein coding gene ChrX:108123314-108126244 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036520
 protein coding gene ChrX:110809852-110812767 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033348
 protein coding gene ChrX:104392779-104395725 (+)
CAST/EiJ MGP_CASTEiJ_G0034987
 protein coding gene ChrX:92071075-92074002 (+)
CBA/J MGP_CBAJ_G0035677
 protein coding gene ChrX:114308288-114311214 (+)
DBA/2J MGP_DBA2J_G0035830
 protein coding gene ChrX:106704471-106707394 (+)
FVB/NJ MGP_FVBNJ_G0035771
 protein coding gene ChrX:106068959-106071885 (+)
LP/J MGP_LPJ_G0035923
 protein coding gene ChrX:108592595-108595522 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035802
 protein coding gene ChrX:119526639-119529554 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036547
 protein coding gene ChrX:107222799-107225729 (+)
PWK/PhJ MGP_PWKPhJ_G0034683
 protein coding gene ChrX:89602783-89605723 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034512
 protein coding gene ChrX:92946911-92949839 (+)
WSB/EiJ MGP_WSBEiJ_G0035125
 protein coding gene ChrX:105927217-105930140 (+)



Homology
more
  • Human Ortholog
    POU3F4, POU class 3 homeobox 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU3F4, POU class 3 homeobox 4
  • Synonyms
    BRAIN-4, BRN-4, BRN4, DFN3, DFNX2, OCT-9, OTF-9, OTF9
  • Links
    NCBI Gene ID: 5456
    neXtProt AC: NX_P49335
    UniProt: P49335

  • Chr Location
    Xq21.1; chrX:83508290-83512127 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human POU3F4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 4 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for spontaneous, radiation-induced and targeted null mutations exhibit developmental malformations of the inner ear resulting in head-shaking and hearing loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1087
  • Tissues
    247
  • cDNA Data
    12
  • Literature Summary
    86
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056854 Ensembl Gene Model | MGI Sequence Detail 2928 C57BL/6J ±  kb
    transcript ENSMUST00000078229 Ensembl | MGI Sequence Detail 2928 Not Applicable  
    polypeptide ENSMUSP00000077354 Ensembl | MGI Sequence Detail 361 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 2
      cDNA 17
      Primer pair 3
      Other 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13084, MGD-MRK-14438, MGD-MRK-1626, MGD-MRK-18721, MGI:98317
    References
    more
    • Summaries
      All 138
      Developmental Gene Expression 86
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:487 Hara Y, et al., Structure and evolution of four POU domain genes expressed in mouse brain. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3280-4
    • Latest
      J:349696 Lekkos K, et al., Validation of positional candidates Rps6ka6 and Pou3f4 for a locus associated with skeletal muscle mass variability. G3 (Bethesda). 2024 May 7;14(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory