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Pou2f1 Gene Detail
Summary
  • Symbol
    Pou2f1
  • Name
    POU domain, class 2, transcription factor 1
  • Synonyms
    2810482H01Rik, oct-1, Oct1, Oct-1A, Oct-1B, Oct-1C, Oct-1z, Otf-1, Otf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101898
    NCBI Gene: 18986
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    3 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:165692723-165830247 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 73.21 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2423 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101898
 protein coding gene Chr1:165692719-165830318 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016699
 protein coding gene Chr1:171375958-171519215 (-)
A/J MGP_AJ_G0016680
 protein coding gene Chr1:164395341-164532865 (-)
AKR/J MGP_AKRJ_G0016646
 protein coding gene Chr1:169356379-169497709 (-)
BALB/cJ MGP_BALBcJ_G0016641
 protein coding gene Chr1:164875744-165014753 (-)
C3H/HeJ MGP_C3HHeJ_G0016465
 protein coding gene Chr1:169579415-169719680 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017102
 protein coding gene Chr1:177126973-177267216 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014811
 protein coding gene Chr1:156268187-156408614 (-)
CAST/EiJ MGP_CASTEiJ_G0016045
 protein coding gene Chr1:169178250-169319355 (-)
CBA/J MGP_CBAJ_G0016440
 protein coding gene Chr1:183432968-183577847 (-)
DBA/2J MGP_DBA2J_G0016546
 protein coding gene Chr1:163265623-163403600 (-)
FVB/NJ MGP_FVBNJ_G0016544
 protein coding gene Chr1:161702288-161838783 (-)
LP/J MGP_LPJ_G0016617
 protein coding gene Chr1:172440663-172590841 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016569
 protein coding gene Chr1:190889768-191032810 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017138
 protein coding gene Chr1:169223670-169361410 (-)
PWK/PhJ MGP_PWKPhJ_G0015831
 protein coding gene Chr1:162465544-162607287 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015618
 protein coding gene Chr1:168064780-168206819 (-)
WSB/EiJ MGP_WSBEiJ_G0016107
 protein coding gene Chr1:169370983-169509784 (-)



Homology
more
  • Human Ortholog
    POU2F1, POU class 2 homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU2F1, POU class 2 homeobox 1
  • Synonyms
    OCT1, oct-1B, Oct1Z, OTF1
  • Links
    NCBI Gene ID: 5451
    neXtProt AC: NX_P14859
    UniProt: P14859

  • Chr Location
    1q24.2; chr1:167220876-167427345 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in prenatal lethality, with earlier lethality on either a 129/Sv or C57BL/6 background than a mixed 129/Sv and C57BL/6 background. Embryos show decreased erythropoiesis and partial penetrance of small lens size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    116
  • cDNA Data
    21
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026565 Ensembl Gene Model | MGI Sequence Detail 137525 C57BL/6J ±  kb
    transcript ENSMUST00000160260 Ensembl | MGI Sequence Detail 13022 Not Applicable  
    polypeptide ENSMUSP00000124738 Ensembl | MGI Sequence Detail 793 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 5
      cDNA 21
      Primer pair 6
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12974, MGD-MRK-13060, MGD-MRK-13066, MGD-MRK-18725, MGI:2443655
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 19
      Gene Ontology 19
      Phenotypes 24
    • Earliest
      J:9555 Sturm RA, et al., The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain. Genes Dev. 1988 Dec;2(12A):1582-99
    • Latest
      J:326544 Alam SS, et al., Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis. Dis Model Mech. 2022 Jun 1;15(6):dmm049544
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory