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Pla2g5 Gene Detail
Summary
  • Symbol
    Pla2g5
  • Name
    phospholipase A2, group V
  • Synonyms
    sPLA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101899
    NCBI Gene: 18784
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:138526558-138590784 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.57 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2293 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101899
 protein coding gene Chr4:138526555-138590793 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029004
 protein coding gene Chr4:141585204-141655884 (-)
A/J MGP_AJ_G0028963
 protein coding gene Chr4:135508353-135574554 (-)
AKR/J MGP_AKRJ_G0028915
 protein coding gene Chr4:139386051-139451319 (-)
BALB/cJ MGP_BALBcJ_G0028987
 protein coding gene Chr4:136184063-136249944 (-)
C3H/HeJ MGP_C3HHeJ_G0028701
 protein coding gene Chr4:139759286-139826897 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029428
 protein coding gene Chr4:146591775-146680821 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026699
 protein coding gene Chr4:128488825-128549295 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0028666
 protein coding gene Chr4:150816712-150895239 (-)
DBA/2J MGP_DBA2J_G0028815
 protein coding gene Chr4:135891235-135957435 (-)
FVB/NJ MGP_FVBNJ_G0028782
 protein coding gene Chr4:134920125-134987436 (-)
LP/J MGP_LPJ_G0028914
 protein coding gene Chr4:141666031-141737891 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028808
 protein coding gene Chr4:154771965-154840388 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029466
 protein coding gene Chr4:139918202-139986774 (-)
PWK/PhJ MGP_PWKPhJ_G0027854
 protein coding gene Chr4:132749215-132818785 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027679
 protein coding gene Chr4:135674161-135744726 (-)
WSB/EiJ MGP_WSBEiJ_G0028211
 protein coding gene Chr4:140156113-140225785 (-)



Homology
more
  • Human Ortholog
    PLA2G5, phospholipase A2 group V
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G5, phospholipase A2 group V
  • Synonyms
    FRFB, GV-PLA2, hVPLA(2), PLA2-10
  • Links
    NCBI Gene ID: 5322
    neXtProt AC: NX_P39877
    UniProt: P39877

  • Chr Location
    1p36.13; chr1:20028179-20091911 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLA2G5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 6 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced acute zymosan-induced peritonitis and arachadonic acid metabolite release from stimulated peritoneal macrophages. Mice homozygous for a different knock-out allele exhibit reduced response to myocardial ischemia/reperfusion injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1347
  • Tissues
    154
  • cDNA Data
    11
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18784 NCBI Gene Model | MGI Sequence Detail 64227 C57BL/6J ±  kb
    transcript NM_001122954 RefSeq | MGI Sequence Detail 2137 C57BL/6  
    polypeptide P97391 UniProt | EBI | MGI Sequence Detail 137 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 2
      cDNA 11

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18726
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 6
      Gene Ontology 15
      Phenotypes 39
    • Earliest
      J:30355 Dennis EA, Diversity of group types, regulation, and function of phospholipase A2. J Biol Chem. 1994 May 6;269(18):13057-60
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory