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Mmp14 Gene Detail
Summary
  • Symbol
    Mmp14
  • Name
    matrix metallopeptidase 14 (membrane-inserted)
  • Synonyms
    Membrane type 1-MMP, MT1-MMP, sabe
  • Feature Type
    protein coding gene
  • IDs
    MGI:101900
    NCBI Gene: 17387
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54669055-54679913 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.79 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    253 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101900
 protein coding gene Chr14:54669055-54682821 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021309
 protein coding gene Chr14:48377410-48386894 (+)
A/J MGP_AJ_G0021268
 protein coding gene Chr14:47442367-47453044 (+)
AKR/J MGP_AKRJ_G0021244
 protein coding gene Chr14:49156082-49165568 (+)
BALB/cJ MGP_BALBcJ_G0021272
 protein coding gene Chr14:47412017-47421514 (+)
C3H/HeJ MGP_C3HHeJ_G0021052
 protein coding gene Chr14:48840637-48850195 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021711
 protein coding gene Chr14:50836333-50846840 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019255
 protein coding gene Chr14:45860422-45869894 (+)
CAST/EiJ MGP_CASTEiJ_G0020571
 protein coding gene Chr14:45083424-45094093 (+)
CBA/J MGP_CBAJ_G0021019
 protein coding gene Chr14:52337708-52348381 (+)
DBA/2J MGP_DBA2J_G0021140
 protein coding gene Chr14:47186054-47196740 (+)
FVB/NJ MGP_FVBNJ_G0021122
 protein coding gene Chr14:46639096-46648580 (+)
LP/J MGP_LPJ_G0021214
 protein coding gene Chr14:49385992-49395680 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021146
 protein coding gene Chr14:51778127-51788780 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021737
 protein coding gene Chr14:48338558-48349948 (+)
PWK/PhJ MGP_PWKPhJ_G0020317
 protein coding gene Chr14:43712481-43723299 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020145
 protein coding gene Chr14:44330200-44340860 (+)
WSB/EiJ MGP_WSBEiJ_G0020624
 protein coding gene Chr14:48637475-48647547 (+)



Homology
more
  • Human Ortholog
    MMP14, matrix metallopeptidase 14
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP14, matrix metallopeptidase 14
  • Synonyms
    MMP-14, MMP-X1, MT1-MMP, MT1MMP, MT-MMP, MT-MMP 1, MTMMP1, WNCHRS
  • Links
    NCBI Gene ID: 4323
    neXtProt AC: NX_P50281
    UniProt: P50281

  • Chr Location
    14q11.2; chr14:22836560-22849041 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Mmp14 mouse models; 3 with human MMP14 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    121 phenotypes from 7 alleles in 11 genetic backgrounds
    53 phenotypes from multigenic genotypes
    2 images
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mutations may lead to postnatal or premature death, craniofacial anomalies, skeletal dysplasia, low body weight, reduced bone formation and chondrocyte proliferation, arthritis, and fibrosis as well as defects in angiogenesis and lung, tooth,kidney, and submaxillary gland development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    896
  • Tissues
    97
  • cDNA Data
    20
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17387 NCBI Gene Model | MGI Sequence Detail 10859 C57BL/6J ±  kb
    transcript NM_008608 RefSeq | MGI Sequence Detail 3801 ZRU/MplStud  
    polypeptide P53690 UniProt | EBI | MGI Sequence Detail 582 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 2
      cDNA 21
      Primer pair 12
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-18727, MGI:2145621, MGI:3717409
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 57
      Diseases 1
      Gene Ontology 12
      Phenotypes 89
    • Earliest
      J:22683 Sato H, et al., A matrix metalloproteinase expressed on the surface of invasive tumour cells [see comments]. Nature. 1994 Jul 7;370(6484):61-5
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory