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Klra7 Gene Detail
Summary
  • Symbol
    Klra7
  • Name
    killer cell lectin-like receptor, subfamily A, member 7
  • Synonyms
    LGL-1, Ly49g, Ly49g1, Ly-49G.1, Ly49g2, Ly-49G.2, Ly-49G.3
  • Feature Type
    protein coding gene
  • IDs
    MGI:101901
    NCBI Gene: 16638
  • Member of
    Klra cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:130195568-130210285 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    241 from dbSNP Build 142
  • Strain Annotations
    11
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101901
 protein coding gene Chr6:130195568-130210285 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031364
 protein coding gene Chr6:133994086-134011768 (-)
A/J MGP_AJ_G0031336
 protein coding gene Chr6:128587336-128602807 (-)
AKR/J MGP_AKRJ_G0031264
 protein coding gene Chr6:132079385-132091411 (-)
BALB/cJ MGP_BALBcJ_G0031345
 protein coding gene Chr6:128480748-128493834 (-)
C3H/HeJ MGP_C3HHeJ_G0031068
 protein coding gene Chr6:132306268-132321644 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031801
 protein coding gene Chr6:137384719-137624293 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031185
 protein coding gene Chr6:127712254-127725484 (-)
FVB/NJ MGP_FVBNJ_G0031137
 protein coding gene Chr6:126503131-126522552 (-)
LP/J MGP_LPJ_G0031266
 protein coding gene Chr6:133901691-134275339 (-)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0031838
 protein coding gene Chr6:132423956-132468404 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Knockout in conjunction with Klra1 KO Klra1em1Wyok results in reduced resistance to a mutated (m157 KO) murine cytomegalovirus (MCMV) and 50% reduction in total NK cell level.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16638 NCBI Gene Model | MGI Sequence Detail 14718 C57BL/6J ±  kb
transcript NM_014194 RefSeq | MGI Sequence Detail 1075 ZRU/MplStud  
polypeptide Q60654 UniProt | EBI | MGI Sequence Detail 280 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    Genomic 18
    cDNA 11
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18728
References
more
  • Summaries
    All 46
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:10723 Yokoyama WM, et al., Chromosomal location of the Ly-49 (A1, YE1/48) multigene family. Genetic association with the NK 1.1 antigen. J Immunol. 1990 Oct 1;145(7):2353-8
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory