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Klra5 Gene Detail
Summary
  • Symbol
    Klra5
  • Name
    killer cell lectin-like receptor, subfamily A, member 5
  • Synonyms
    Ly49e
  • Feature Type
    protein coding gene
  • IDs
    MGI:101903
    NCBI Gene: 16636
  • Member of
    Klra cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:129874715-129890188 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    15
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101903
 protein coding gene Chr6:129874715-129894613 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031362
 protein coding gene Chr6:133600074-133604227 (-)
A/J MGP_AJ_G0031333
 protein coding gene Chr6:128464604-128484698 (-)
AKR/J MGP_AKRJ_G0031261
 protein coding gene Chr6:131949640-131970600 (-)
BALB/cJ MGP_BALBcJ_G0031340
 protein coding gene Chr6:128100848-128123045 (-)
C3H/HeJ MGP_C3HHeJ_G0031063
 protein coding gene Chr6:132180569-132198695 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031799
 protein coding gene Chr6:137213070-137372875 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031024
 protein coding gene Chr6:142460285-142482434 (-)
DBA/2J MGP_DBA2J_G0031182
 protein coding gene Chr6:127404136-127421978 (-)
FVB/NJ MGP_FVBNJ_G0031131
 protein coding gene Chr6:126312051-126330872 (-)
LP/J MGP_LPJ_G0031262
 protein coding gene Chr6:133778784-133784883 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031170
 protein coding gene Chr6:146378243-146401573 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031832
 protein coding gene Chr6:132024515-132659450 (-)
PWK/PhJ MGP_PWKPhJ_G0030160
 protein coding gene Chr6:125658260-125766984 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029989
 protein coding gene Chr6:130071978-130492649 (-)
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Mice homozygous for a knock-out allele exhibit normal NK and T cell morphology and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16636 NCBI Gene Model | MGI Sequence Detail 15474 C57BL/6J ±  kb
transcript NM_008463 RefSeq | MGI Sequence Detail 1155 ZRU/MplStud  
polypeptide Q60652 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 9
    cDNA 5
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-18730
References
more
  • Summaries
    All 39
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:10723 Yokoyama WM, et al., Chromosomal location of the Ly-49 (A1, YE1/48) multigene family. Genetic association with the NK 1.1 antigen. J Immunol. 1990 Oct 1;145(7):2353-8
  • Latest
    J:314632 Van Acker A, et al., The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression. Cancer Immunol Immunother. 2016 Nov;65(11):1365-1375
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory