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Klra1 Gene Detail
Summary
  • Symbol
    Klra1
  • Name
    killer cell lectin-like receptor, subfamily A, member 1
  • Synonyms
    Ly49A, Ly49o129
  • Feature Type
    protein coding gene
  • IDs
    MGI:101907
    NCBI Gene: 16627
  • Member of
    Klra cluster
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:130340881-130363837 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    406 from dbSNP Build 142
  • Strain Annotations
    15
  • PCR
    2
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101907
 protein coding gene Chr6:130340880-130363837 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031363
 protein coding gene Chr6:133682713-133738257 (-)
A/J MGP_AJ_G0031337
 protein coding gene Chr6:128817177-128985749 (-)
AKR/J MGP_AKRJ_G0031269
 protein coding gene Chr6:132398026-132422338 (-)
BALB/cJ MGP_BALBcJ_G0031348
 protein coding gene Chr6:128646458-128670048 (-)
C3H/HeJ MGP_C3HHeJ_G0031071
 protein coding gene Chr6:132617581-132758348 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031806
 protein coding gene Chr6:137782720-137807048 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030442
 protein coding gene Chr6:132643682-132654592 (+)
CBA/J MGP_CBAJ_G0031029
 protein coding gene Chr6:143043144-143074912 (-)
DBA/2J MGP_DBA2J_G0031189
 protein coding gene Chr6:127856247-127882514 (-)
FVB/NJ no annotation
LP/J MGP_LPJ_G0031269
 protein coding gene Chr6:134345068-134371650 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031172
 protein coding gene Chr6:146475281-146484829 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031839
 protein coding gene Chr6:132636689-132659351 (-)
PWK/PhJ MGP_PWKPhJ_G0030162
 protein coding gene Chr6:125719277-125918026 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029990
 protein coding gene Chr6:130225735-130443420 (-)
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of the active domain affects NK-cell inhibition, licensing, and receptor repertoire development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16627 NCBI Gene Model | MGI Sequence Detail 22957 C57BL/6J ±  kb
transcript NM_016659 RefSeq | MGI Sequence Detail 1667 ZRU/MplStud  
polypeptide P20937 UniProt | EBI | MGI Sequence Detail 262 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    Genomic 24
    cDNA 6
    Primer pair 5

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18734
References
more
  • Summaries
    All 86
    Gene Ontology 7
    Phenotypes 16
  • Earliest
    J:16721 Yokoyama WM, et al., A murine T lymphocyte antigen belongs to a supergene family of type II integral membrane proteins. J Immunol. 1989 Aug 15;143(4):1379-86
  • Latest
    J:333878 Kissiov DU, et al., Binary outcomes of enhancer activity underlie stable random monoallelic expression. Elife. 2022 May 26;11:e74204
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory