Dusp2 MGI Mouse Gene Detail - MGI:101911 - dual specificity phosphatase 2

Symbol

Dusp2
Name

dual specificity phosphatase 2
Synonyms

PAC1

Feature Type

protein coding gene
IDs

MGI:101911
NCBI Gene: 13537
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:127178079-127180296 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.93 cM
Mapping Data

1 experiment

SNPs within 2kb

114 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101911	protein coding gene	Chr2:127178079-127180297 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026456	protein coding gene	Chr2:130626779-130628996 (+)
A/J	MGP_AJ_G0026420	protein coding gene	Chr2:125321749-125323966 (+)
AKR/J	MGP_AKRJ_G0026395	protein coding gene	Chr2:128900464-128902681 (+)
BALB/cJ	MGP_BALBcJ_G0026432	protein coding gene	Chr2:125590543-125592760 (+)
C3H/HeJ	MGP_C3HHeJ_G0026175	protein coding gene	Chr2:129416541-129418717 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026877	protein coding gene	Chr2:134715791-134718008 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024254	protein coding gene	Chr2:120163988-120166194 (+)
CAST/EiJ	MGP_CASTEiJ_G0025636	protein coding gene	Chr2:129625534-129627710 (+)
CBA/J	MGP_CBAJ_G0026155	protein coding gene	Chr2:139704769-139706945 (+)
DBA/2J	MGP_DBA2J_G0026289	protein coding gene	Chr2:124731731-124733907 (+)
FVB/NJ	MGP_FVBNJ_G0026253	protein coding gene	Chr2:123378758-123380975 (+)
LP/J	MGP_LPJ_G0026394	protein coding gene	Chr2:130854834-130857051 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026273	protein coding gene	Chr2:143735717-143737934 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026932	protein coding gene	Chr2:128929590-128931807 (+)
PWK/PhJ	MGP_PWKPhJ_G0025372	protein coding gene	Chr2:124277112-124279288 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025174	protein coding gene	Chr2:128007349-128009562 (+)
WSB/EiJ	MGP_WSBEiJ_G0025710	protein coding gene	Chr2:129822801-129825018 (+)

Human Ortholog

DUSP2, dual specificity phosphatase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP2, dual specificity phosphatase 2
Synonyms

PAC-1, PAC1
Links

HGNC:3068

NCBI Gene ID: 1844

neXtProt AC: NX_Q05923

UniProt: Q05923
Chr Location

2q11.2; chr2:96143169-96145440 (-) GRCh38

MGI Vertebrate Homology

Dusp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DUSP2
Protein SuperFamily

MAPK_Ptase
Gene Tree

Dusp2

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Dusp2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in reduced inflammatory responses in induced rheumatoid arthritis.

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All GO Annotations

31
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

753
Tissues

30
cDNA Data

20
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS16699.1

Ensembl

ENSMUSG00000027368 (Evidence)
NCBI Gene

13537

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027368	Ensembl Gene Model \| MGI Sequence Detail	2218	C57BL/6J	± kb
transcript	ENSMUST00000028846	Ensembl \| MGI Sequence Detail	1617	Not Applicable
polypeptide	ENSMUSP00000028846	Ensembl \| MGI Sequence Detail	318	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006746 dual specificity protein phosphatase 2

(term hierarchy)
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR008343 Mitogen-activated protein (MAP) kinase phosphatase

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 23

Genomic 2

cDNA 20

Primer pair 1

Microarray probesets 3

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MGD-MRK-18740

Summaries

All 42

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 10
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Dusp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr637	Chr2:127177956-127177966 (+)	-118 bp
Tssr20008	Chr2:127178072-127178086 (+)	0 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24