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Cpe Gene Detail
Summary
  • Symbol
    Cpe
  • Name
    carboxypeptidase E
  • Synonyms
    carboxypeptidase H, CPH, Cph-1, Cph1, NF-alpha1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101932
    NCBI Gene: 12876
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:65045576-65146088 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 32.30 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3353 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101932
 protein coding gene Chr8:65045576-65146143 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033642
 protein coding gene Chr8:64596237-64705607 (-)
A/J MGP_AJ_G0033624
 protein coding gene Chr8:61877178-61978965 (-)
AKR/J MGP_AKRJ_G0033549
 protein coding gene Chr8:63645912-63750117 (-)
BALB/cJ MGP_BALBcJ_G0033620
 protein coding gene Chr8:62164413-62265213 (-)
C3H/HeJ MGP_C3HHeJ_G0033330
 protein coding gene Chr8:64382650-64489344 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034137
 protein coding gene Chr8:67017251-67122882 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031084
 protein coding gene Chr8:56922992-57024872 (-)
CAST/EiJ MGP_CASTEiJ_G0032655
 protein coding gene Chr8:63826812-63938498 (-)
CBA/J MGP_CBAJ_G0033308
 protein coding gene Chr8:69519243-69628718 (-)
DBA/2J MGP_DBA2J_G0033462
 protein coding gene Chr8:61641806-61800413 (-)
FVB/NJ MGP_FVBNJ_G0033403
 protein coding gene Chr8:60909333-61016510 (-)
LP/J MGP_LPJ_G0033550
 protein coding gene Chr8:64636023-64743827 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033447
 protein coding gene Chr8:72082406-72186792 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034155
 protein coding gene Chr8:63940066-64040683 (-)
PWK/PhJ MGP_PWKPhJ_G0032364
 protein coding gene Chr8:61023662-61128426 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032200
 protein coding gene Chr8:62882024-63023758 (-)
WSB/EiJ MGP_WSBEiJ_G0032772
 protein coding gene Chr8:64320324-64427769 (-)



Homology
more
  • Human Ortholog
    CPE, carboxypeptidase E
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPE, carboxypeptidase E
  • Synonyms
    BDVS, CPH, IDDHH
  • Links
    NCBI Gene ID: 1363
    neXtProt AC: NX_P16870
    UniProt: P16870

  • Chr Location
    4q32.3; chr4:165361194-165498547 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cpe mouse models; 4 with human CPE associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    68 phenotypes from 3 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous or a targeted null mutation display progressive obesity, abnormal blood glucose and lipid regulation, and have reduced fertility. Aberrant prohormone processing and secretion appears to be the cause of these phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1002
  • Tissues
    207
  • cDNA Data
    12
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037852 Ensembl Gene Model | MGI Sequence Detail 100513 C57BL/6J ±  kb
    transcript ENSMUST00000048967 Ensembl | MGI Sequence Detail 2117 Not Applicable  
    polypeptide ENSMUSP00000048555 Ensembl | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 1
      cDNA 15
      Primer pair 7
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-18763, MGD-MRK-2106, MGD-MRK-2107, MGD-MRK-9713, MGI:2142890
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 14
      Diseases 2
      Gene Ontology 10
      Phenotypes 73
    • Earliest
      J:10872 Coleman DL, et al., Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse. J Hered. 1990 Nov-Dec;81(6):424-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory