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Slc9a1 Gene Detail
Summary
  • Symbol
    Slc9a1
  • Name
    solute carrier family 9 (sodium/hydrogen exchanger), member 1
  • Synonyms
    antiporter, Apnh, Nhe-1, Nhe1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102462
    NCBI Gene: 20544
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133097022-133151013 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.25 cM, cytoband D3-E
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1169 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102462
 protein coding gene Chr4:133097017-133151013 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028893
 protein coding gene Chr4:135606295-135663365 (+)
A/J MGP_AJ_G0028852
 protein coding gene Chr4:129943017-129996503 (+)
AKR/J MGP_AKRJ_G0028805
 protein coding gene Chr4:133632204-133688007 (+)
BALB/cJ MGP_BALBcJ_G0028875
 protein coding gene Chr4:130564384-130617991 (+)
C3H/HeJ MGP_C3HHeJ_G0028589
 protein coding gene Chr4:133880896-133935945 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029317
 protein coding gene Chr4:140494072-140549067 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026588
 protein coding gene Chr4:123018082-123072028 (+)
CAST/EiJ MGP_CASTEiJ_G0028022
 protein coding gene Chr4:131991311-132043892 (+)
CBA/J MGP_CBAJ_G0028555
 protein coding gene Chr4:144154460-144219864 (+)
DBA/2J MGP_DBA2J_G0028704
 protein coding gene Chr4:130360788-130416784 (+)
FVB/NJ MGP_FVBNJ_G0028671
 protein coding gene Chr4:129233499-129289143 (+)
LP/J MGP_LPJ_G0028805
 protein coding gene Chr4:135737499-135792218 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028697
 protein coding gene Chr4:148678207-148734843 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029355
 protein coding gene Chr4:134054110-134112984 (+)
PWK/PhJ MGP_PWKPhJ_G0027743
 protein coding gene Chr4:127075478-127130404 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027569
 protein coding gene Chr4:129893714-129946518 (+)
WSB/EiJ MGP_WSBEiJ_G0028102
 protein coding gene Chr4:134226690-134282953 (+)



Homology
more
  • Human Ortholog
    SLC9A1, solute carrier family 9 member A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC9A1, solute carrier family 9 member A1
  • Synonyms
    APNH, LIKNS, NHE-1, NHE1, PPP1R143
  • Links
    NCBI Gene ID: 6548
    neXtProt AC: NX_P19634
    UniProt: P19634

  • Chr Location
    1p36.11; chr1:27098809-27166981 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SLC9A1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 3 alleles in 6 genetic backgrounds
    1 images
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Two-thirds of homozygous null mice die before weaning with reduced body weight, ataxia, a relatively mild stomach phenotype, and a postmortem appearance suggestive of death by a convulsive seizure. Homozygotes also display impaired fluid secretion and NaCl absorption in their parotid glands.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    113
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    938
  • Tissues
    138
  • cDNA Data
    109
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20544 NCBI Gene Model | MGI Sequence Detail 53992 C57BL/6J ±  kb
    transcript NM_001358455 RefSeq | MGI Sequence Detail 4820 ZRU/MplStud  
    polypeptide Q61165 UniProt | EBI | MGI Sequence Detail 820 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 119
      cDNA 112
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12876, MGD-MRK-1362, MGD-MRK-19299, MGI:1196422, MGI:2140598
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 11
      Gene Ontology 16
      Phenotypes 51
    • Earliest
      J:12498 Mattei MG, et al., Localization of the antiporter gene (APNH) and chromosomal segment homology between human 1p, mouse 4 and Chinese hamster 2q. Cytogenet Cell Genet. 1989;51:1041 (Abstr.)
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory