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mt-Tk Gene Detail
Summary
  • Symbol
    mt-Tk
  • Name
    mitochondrially encoded tRNA lysine
  • Synonyms
    tRNA, tRNA-Lys, TrnK tRNA
  • Feature Type
    tRNA gene
  • IDs
    MGI:102483
    NCBI Gene: 17734
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrMT:7700-7764 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome MT, Syntenic
Strain
Comparison
more
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102483
 tRNA gene ChrMT:7700-7764 (+)
129S1/SvImJ MGP_129S1SvImJ_G0000308
 tRNA gene Chr11:43216705-43216757 (-)
A/J MGP_AJ_G0000280
 tRNA gene Chr11:41557700-41557752 (-)
AKR/J MGP_AKRJ_G0000271
 tRNA gene Chr11:42771833-42771885 (-)
BALB/cJ MGP_BALBcJ_G0000274
 tRNA gene Chr11:41749716-41749768 (-)
C3H/HeJ MGP_C3HHeJ_G0000261
 tRNA gene Chr11:42811127-42811179 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0000156
 tRNA gene Chr11:39597643-39597701 (-)
CAST/EiJ MGP_CASTEiJ_G0000254
 tRNA gene Chr11:42897051-42897103 (-)
CBA/J MGP_CBAJ_G0000255
 tRNA gene Chr11:46602084-46602136 (-)
DBA/2J MGP_DBA2J_G0000257
 tRNA gene Chr11:41323542-41323594 (-)
FVB/NJ MGP_FVBNJ_G0000271
 tRNA gene Chr11:41000706-41000758 (-)
LP/J MGP_LPJ_G0000313
 tRNA gene Chr11:43467519-43467571 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0000274
 tRNA gene Chr11:48222681-48222733 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0000383
 tRNA gene Chr2:20041335-20041394 (-)
PWK/PhJ MGP_PWKPhJ_G0000214
 tRNA gene Chr11:41377672-41377724 (-)
SPRET/EiJ MGP_SPRETEiJ_G0000198
 tRNA gene Chr5:4477410-4477469 (+)
WSB/EiJ MGP_WSBEiJ_G0000262
 tRNA gene Chr4:90377108-90377172 (-)



Homology
more
  • Human Ortholog
    TRNK, tRNA-Lys
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRNK, tRNA-Lys
  • Synonyms
    MTTK
  • Links
    NCBI Gene ID: 4566

  • Chr Location
    chrMT:8295-8364 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with mt-Tk mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Transmitochondrial mice carrying high proportions of mutant G7731A mitochondrial DNA exhibit respiration defects in skeletal muscle and kidney, decreased body length, muscle weakeness, and absent oocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      70
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17734 NCBI Gene Model | MGI Sequence Detail 65 C57BL/6J ±  kb
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 52
      Other 52
    Other
    Accession IDs
    less
    MGD-MRK-19320
    References
    more
    • Summaries
      All 28
      Diseases 2
      Gene Ontology 1
      Phenotypes 16
    • Earliest
      J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
    • Latest
      J:303932 Ishikawa K, et al., Attempts to understand the mechanisms of mitochondrial diseases: The reverse genetics of mouse models for mitochondrial disease. Biochim Biophys Acta Gen Subj. 2021 Mar;1865(3):129835
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/02/2024
    MGI 6.24     		The Jackson Laboratory