mt-Nd4l MGI Mouse Gene Detail - MGI:102497 - mitochondrially encoded NADH dehydrogenase 4L

mt-Nd4l Gene Detail

Symbol

mt-Nd4l
Name

mitochondrially encoded NADH dehydrogenase 4L
Synonyms

ENSMUSG00000065947, URF4L

Feature Type

protein coding gene
IDs

MGI:102497
NCBI Gene: 17720
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

ChrMT:9877-10173 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome MT, Syntenic
Mapping Data

1 experiment

SNPs within 2kb

29 from dbSNP Build 142
Strain Annotations

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102497	protein coding gene	ChrMT:9877-10173 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

ND4L, NADH dehydrogenase subunit 4L

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ND4L, NADH dehydrogenase subunit 4L
Synonyms

MTND4L
Links

HGNC:7460

NCBI Gene ID: 4539

neXtProt AC: NX_P03901

UniProt: P03901
Chr Location

chrMT:10470-10766 (+) GRCh38

MGI Vertebrate Homology

mt-Nd4l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ND4L
Gene Tree

mt-Nd4l

Diseases

2 with human ND4L associations

				Human Disease	Mouse Models
				diabetes mellitus IDs diabetes mellitus DOID:9351 ICD10CM:E08-E13 ICD9CM:250 MESH:D003920 NCI:C2985 UMLS_CUI:C0011849
				Leber hereditary optic neuropathy IDs Leber hereditary optic neuropathy DOID:705 ICD10CM:H47.22 MESH:D029242 NCI:C84808 OMIM:535000 UMLS_CUI:C0917796

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

15 phenotype references

All Mutations and Alleles

2
Spontaneous

2
Genomic Mutations

1 involving mt-Nd4l
Find Mice (IMSR)

0 strains or lines available

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All GO Annotations

15
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

1
cDNA Data

5
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

65
RefSeq

1
UniProt

2

Ensembl

ENSMUSG00000065947 (Evidence)
NCBI Gene

17720

			Length	Strain/Species	Flank
genomic	17720	NCBI Gene Model \| MGI Sequence Detail	297	C57BL/6J	± kb
transcript	BC050862	GenBank \| ENA \| DDBJ \| MGI Sequence Detail	3663	Not Specified
polypeptide	P03903	UniProt \| EBI \| MGI Sequence Detail	98	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010692 NADH-ubiquinone oxidoreductase chain 4L

(term hierarchy)
PDB

6G2J, 6G72, 6ZR2, 6ZTQ, 7AK5, 7AK6, 7B93, 7PSA, 8C2S, 8CA3, 8CA5, 8OLT, 8OM1, 8PW5, 8PW6, 8PW7, 8RGP, 8RGQ, 8RGR, 8RGT
EC

7.1.1.2
InterPro Domains

IPR001133 NADH-ubiquinone oxidoreductase chain 4L/K

IPR039428 NADH-ubiquinone oxidoreductase chain 4L/Mnh complex subunit C1-like

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All nucleic 59

cDNA 6

Primer pair 1

Other 52

Microarray probesets 2

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MGD-MRK-19334, MGI:3710614

Summaries

All 42

Developmental Gene Expression 2

Diseases 1

Gene Ontology 11

Phenotypes 15
Earliest

J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
Latest

J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071

TSS for mt-Nd4l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160164	ChrMT:9870-9885 (+)	1 bp
Tssr160165	ChrMT:9975-9987 (+)	104 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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