mt-Co3 MGI Mouse Gene Detail - MGI:102502 - mitochondrially encoded cytochrome c oxidase III

mt-Co3 Gene Detail

Symbol

mt-Co3
Name

mitochondrially encoded cytochrome c oxidase III
Synonyms

COIII, COX3

Feature Type

protein coding gene
IDs

MGI:102502
NCBI Gene: 17710
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

ChrMT:8607-9390 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome MT, Syntenic

SNPs within 2kb

12 from dbSNP Build 142
Strain Annotations

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102502	protein coding gene	ChrMT:8607-9390 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

COX3, cytochrome c oxidase subunit III

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COX3, cytochrome c oxidase subunit III
Synonyms

COIII, MTCO3
Links

HGNC:7422

NCBI Gene ID: 4514

neXtProt AC: NX_P00414

UniProt: P00414
Chr Location

chrMT:9207-9990 (+) GRCh38

MGI Vertebrate Homology

mt-Co3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COX3
Gene Tree

mt-Co3

Diseases

1 with human COX3 associations

				Human Disease	Mouse Models
				MELAS syndrome IDs MELAS syndrome DOID:3687 ICD10CM:E88.41 MESH:D017241 NCI:C84885 OMIM:540000 UMLS_CUI:C0162671

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

15 phenotype references

All Mutations and Alleles

3
Spontaneous

3
Genomic Mutations

1 involving mt-Co3
Find Mice (IMSR)

0 strains or lines available

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All GO Annotations

15
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

826
Tissues

118
cDNA Data

8
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Expression Atlas

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All Sequences

60
RefSeq

1
UniProt

2

Ensembl

ENSMUSG00000064358 (Evidence)
NCBI Gene

17710

			Length	Strain/Species	Flank
genomic	17710	NCBI Gene Model \| MGI Sequence Detail	784	C57BL/6J	± kb
transcript	BC012020	GenBank \| ENA \| DDBJ \| MGI Sequence Detail	1616	C57BL/6
polypeptide	P00416	UniProt \| EBI \| MGI Sequence Detail	261	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010689 cytochrome c oxidase subunit 3

(term hierarchy)
PDB

7O37, 7O3C, 7O3E, 8PW5, 8PW6, 8PW7
EC

7.1.1.9
InterPro Domains

IPR024791 Cytochrome c oxidase subunit III

IPR013833 Cytochrome c oxidase, subunit III, 4-helical bundle

IPR033945 Cytochrome c oxidase subunit III domain

IPR000298 Cytochrome c oxidase subunit III-like

IPR035973 Cytochrome c oxidase subunit III-like superfamily
GlyGen

P00416 1 site, 1 O-linked glycan (1 site)

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All nucleic 64

cDNA 10

Primer pair 1

Other 53

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MGD-MRK-19339, MGI:2138394, MGI:2138420, MGI:2138462, MGI:2138508

Summaries

All 55

Developmental Gene Expression 8

Diseases 1

Gene Ontology 10

Phenotypes 15
Earliest

J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
Latest

J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071

TSS for mt-Co3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160159	ChrMT:8600-8616 (+)	1 bp
Tssr160160	ChrMT:8618-8619 (+)	12 bp
Tssr160161	ChrMT:8942-8953 (+)	341 bp
Tssr160162	ChrMT:8962-8969 (+)	359 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24