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mt-Co1 Gene Detail
Summary
  • Symbol
    mt-Co1
  • Name
    mitochondrially encoded cytochrome c oxidase I
  • Synonyms
    CCOI, COI, COX 1, COX1, CoxI, mt-Co1-201
  • Feature Type
    protein coding gene
  • IDs
    MGI:102504
    NCBI Gene: 17708
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    ChrMT:5328-6872 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome MT, Syntenic
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102504
 protein coding gene ChrMT:5328-6872 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0025337
 protein coding gene Chr2:20169723-20174285 (+)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0025124
 protein coding gene Chr2:20078681-20080477 (-)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029551
 protein coding gene Chr6:6854470-6856618 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0025235
 protein coding gene Chr2:19379897-19382379 (+)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    COX1, cytochrome c oxidase subunit I
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX1, cytochrome c oxidase subunit I
  • Synonyms
    COI, MTCO1
  • Links
    NCBI Gene ID: 4512
    neXtProt AC: NX_P00395
    UniProt: P00395

  • Chr Location
    chrMT:5904-7445 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Transmitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in this gene show growth retardation, reduced COX activity in cardiac cells, increased blood lactate levels, mitochondrial myopathy, heart inflammation and edema, abnormal bloodvessel morphology, and severe cardiomyopathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    22
  • cDNA Data
    37
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      92
    • RefSeq
      1
    • UniProt
      6
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17708 NCBI Gene Model | MGI Sequence Detail 1545 C57BL/6J ±  kb
    transcript AK138996 GenBank | ENA | DDBJ | MGI Sequence Detail 1616 C57BL/6J  
    polypeptide P00397 UniProt | EBI | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 37
      Primer pair 3
      Other 56

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-19341, MGI:2138416, MGI:2138422, MGI:2138439, MGI:2138442, MGI:2138443, MGI:2138447, MGI:2138450, MGI:2138454, MGI:2139180
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 46
      Gene Ontology 21
      Phenotypes 8
    • Earliest
      J:22484 Bibb MJ, et al., Sequence and gene organization of mouse mitochondrial DNA. Cell. 1981 Oct;26(2 Pt 2):167-80
    • Latest
      J:355679 Vercellino I, et al., SCAF1 drives the compositional diversity of mammalian respirasomes. Nat Struct Mol Biol. 2024 Jul;31(7):1061-1071
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory