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Adam3 Gene Detail
Summary
  • Symbol
    Adam3
  • Name
    ADAM metallopeptidase domain 3
  • Synonyms
    ADAM3, Cyrn1, Taz83, Taz83, tMDC
  • Feature Type
    protein coding gene
  • IDs
    MGI:102518
    NCBI Gene: 11497
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:25167241-25215868 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 13.09 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1251 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102518
 protein coding gene Chr8:25167241-25216393 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033473
 protein coding gene Chr8:22678781-22730514 (-)
A/J MGP_AJ_G0033453
 protein coding gene Chr8:21881055-21934718 (-)
AKR/J MGP_AKRJ_G0033378
 protein coding gene Chr8:22607629-22658330 (-)
BALB/cJ MGP_BALBcJ_G0033449
 protein coding gene Chr8:22039139-22087686 (-)
C3H/HeJ MGP_C3HHeJ_G0033163
 protein coding gene Chr8:22794333-22849701 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033965
 protein coding gene Chr8:23577712-23633403 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030915
 protein coding gene Chr8:19192758-19242266 (-)
CAST/EiJ MGP_CASTEiJ_G0032489
 protein coding gene Chr8:22213245-22274182 (-)
CBA/J MGP_CBAJ_G0033138
 protein coding gene Chr8:24520885-24583433 (-)
DBA/2J MGP_DBA2J_G0033293
 protein coding gene Chr8:21852748-21902543 (-)
FVB/NJ MGP_FVBNJ_G0033237
 protein coding gene Chr8:21638298-21689293 (-)
LP/J MGP_LPJ_G0033382
 protein coding gene Chr8:22667057-22721521 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033280
 protein coding gene Chr8:24047291-24102395 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033984
 protein coding gene Chr8:22526570-22575979 (-)
PWK/PhJ MGP_PWKPhJ_G0032200
 protein coding gene Chr8:21457570-21508834 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032034
 protein coding gene Chr8:21881512-21938821 (-)
WSB/EiJ MGP_WSBEiJ_G0032605
 protein coding gene Chr8:22740638-22801179 (-)



Homology
more
  • Human Ortholog
    ADAM3A, ADAM metallopeptidase domain 3A (pseudogene)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM3A, ADAM metallopeptidase domain 3A (pseudogene)
  • Synonyms
    ADAM3, CYRN1, tMDCI
  • Links
    NCBI Gene ID: 1587

  • Chr Location
    8p11.22; chr8:39451045-39522989 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ADAM3A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 4 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene are male infertile, due to the inability of the sperm to bind to the zona pellucida. If the zona pellucida is removed sperm-egg membrane fusion happens as expected.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031553 Ensembl Gene Model | MGI Sequence Detail 48628 C57BL/6J ±  kb
    transcript ENSMUST00000033958 Ensembl | MGI Sequence Detail 2743 Not Applicable  
    polypeptide ENSMUSP00000033958 Ensembl | MGI Sequence Detail 822 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19356
    References
    more
    • Summaries
      All 50
      Gene Ontology 15
      Phenotypes 16
    • Earliest
      J:18471 Lemaire L, et al., Chromosomal assignment of three novel mouse genes expressed in testicular cells. Genomics. 1994 May 15;21(2):409-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory