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Pou4f1 Gene Detail
Summary
  • Symbol
    Pou4f1
  • Name
    POU domain, class 4, transcription factor 1
  • Synonyms
    Brn-3, Brn3, Brn-3.0, Brn3a, E130119J07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:102525
    NCBI Gene: 18996
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:104699112-104705435 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 54.21 cM, cytoband E1-E3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102525
 protein coding gene Chr14:104699111-104705554 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021634
 protein coding gene Chr14:101022185-101029682 (-)
A/J MGP_AJ_G0021592
 protein coding gene Chr14:97656073-97662299 (-)
AKR/J MGP_AKRJ_G0021568
 protein coding gene Chr14:100595126-100601129 (-)
BALB/cJ MGP_BALBcJ_G0021598
 protein coding gene Chr14:98016945-98023399 (-)
C3H/HeJ MGP_C3HHeJ_G0021376
 protein coding gene Chr14:100496394-100503897 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022038
 protein coding gene Chr14:105102548-105109489 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019578
 protein coding gene Chr14:94482042-94488323 (-)
CAST/EiJ MGP_CASTEiJ_G0020893
 protein coding gene Chr14:97828912-97835586 (-)
CBA/J MGP_CBAJ_G0021344
 protein coding gene Chr14:108862562-108872801 (-)
DBA/2J MGP_DBA2J_G0021468
 protein coding gene Chr14:97167778-97174169 (-)
FVB/NJ MGP_FVBNJ_G0021445
 protein coding gene Chr14:96129041-96135866 (-)
LP/J MGP_LPJ_G0021536
 protein coding gene Chr14:101833011-101839781 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021472
 protein coding gene Chr14:111701479-111707482 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022061
 protein coding gene Chr14:100119155-100125983 (-)
PWK/PhJ MGP_PWKPhJ_G0020636
 protein coding gene Chr14:94135423-94142027 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020474
 protein coding gene Chr14:96149673-96155721 (-)
WSB/EiJ MGP_WSBEiJ_G0020946
 protein coding gene Chr14:100767052-100775221 (-)



Homology
more
  • Human Ortholog
    POU4F1, POU class 4 homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU4F1, POU class 4 homeobox 1
  • Synonyms
    ATITHS, brn-3A, BRN3A, Oct-T1, RDC-1
  • Links
    NCBI Gene ID: 5457
    neXtProt AC: NX_Q01851
    UniProt: Q01851

  • Chr Location
    13q31.1; chr13:78598362-78603552 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 8 alleles in 9 genetic backgrounds
    5 phenotypes from multigenic genotypes
    6 images
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die within the first day after birth and display various abnormalities in the brain and cranial nerves.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1297
  • Tissues
    214
  • cDNA Data
    16
  • Literature Summary
    374
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048349 Ensembl Gene Model | MGI Sequence Detail 6324 C57BL/6J ±  kb
    transcript ENSMUST00000053016 Ensembl | MGI Sequence Detail 4445 Not Applicable  
    polypeptide ENSMUSP00000060798 Ensembl | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 9
      cDNA 17
      Primer pair 7
      Other 12

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1625, MGD-MRK-1629, MGD-MRK-1630, MGD-MRK-19369, MGI:1925256
    References
    more
    • Summaries
      All 477
      Developmental Gene Expression 374
      Gene Ontology 33
      Phenotypes 76
    • Earliest
      J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
    • Latest
      J:355222 Nord C, et al., Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits. Dev Dyn. 2024 Oct;253(10):922-939
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory