Fau MGI Mouse Gene Detail - MGI:102547 - FAU ubiquitin like and ribosomal protein S30 fusion

Symbol

Fau
Name

FAU ubiquitin like and ribosomal protein S30 fusion
Synonyms

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived), MNSFB, MNSFbeta, monoclonal nonspecific suppressor factor beta

Feature Type

protein coding gene
IDs

MGI:102547
NCBI Gene: 14109
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr19:6107977-6109554 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.34 cM
Mapping Data

4 experiments

SNPs within 2kb

144 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102547	protein coding gene	Chr19:6107874-6109554 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024739	protein coding gene	Chr19:3087108-3088744 (+)
A/J	MGP_AJ_G0024705	protein coding gene	Chr19:2914628-2916480 (+)
AKR/J	MGP_AKRJ_G0024678	protein coding gene	Chr19:3005949-3007576 (+)
BALB/cJ	MGP_BALBcJ_G0024705	protein coding gene	Chr19:2909872-2911510 (+)
C3H/HeJ	MGP_C3HHeJ_G0024473	protein coding gene	Chr19:3023674-3025312 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025152	protein coding gene	Chr19:3144422-3146058 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022585	protein coding gene	Chr19:2844115-2845959 (+)
CAST/EiJ	MGP_CASTEiJ_G0023945	protein coding gene	Chr19:3031143-3032781 (+)
CBA/J	MGP_CBAJ_G0024445	protein coding gene	Chr19:3294587-3296433 (+)
DBA/2J	MGP_DBA2J_G0024572	protein coding gene	Chr19:2901751-2903592 (+)
FVB/NJ	MGP_FVBNJ_G0024538	protein coding gene	Chr19:2915335-2918569 (+)
LP/J	MGP_LPJ_G0024658	protein coding gene	Chr19:3065325-3066961 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024568	protein coding gene	Chr19:3114683-3116977 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025200	protein coding gene	Chr19:3036758-3038394 (+)
PWK/PhJ	MGP_PWKPhJ_G0023691	protein coding gene	Chr19:2934092-2935729 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023496	protein coding gene	Chr19:2994704-2996341 (+)
WSB/EiJ	MGP_WSBEiJ_G0024007	protein coding gene	Chr19:3042676-3044314 (+)

Human Ortholog

FAU, FAU ubiquitin like and ribosomal protein S30 fusion

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAU, FAU ubiquitin like and ribosomal protein S30 fusion
Synonyms

asr1, eS30, FAU1, Fub1, Fubi, MNSFbeta, RPS30, S30
Links

HGNC:3597

NCBI Gene ID: 2197

neXtProt AC: NX_P62861

UniProt: P62861
Chr Location

11q13.1; chr11:65120630-65122177 (-) GRCh38

MGI Vertebrate Homology

Fau stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FAU
Gene Tree

Fau

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

34
Gene trapped

31
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

7 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Female mice heterozygous for a null allele exhibit maternal effect defect impacting embryo survival.

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All GO Annotations

30
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

726
Tissues

3
cDNA Data

293
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fau

ZFIN faua, faub

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All Sequences

69
RefSeq

6
UniProt

4
CCDS

CCDS29489.1

Ensembl

ENSMUSG00000038274 (Evidence)
NCBI Gene

14109

			Length	Strain/Species	Flank
genomic	14109	NCBI Gene Model \| MGI Sequence Detail	1578	C57BL/6J	± kb
transcript	NM_001190436	RefSeq \| MGI Sequence Detail	756	ZRU/MplStud
polypeptide	P62862	UniProt \| EBI \| MGI Sequence Detail	133	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000050152 ubiquitin-like FUBI-ribosomal protein eS30 fusion protein

(term hierarchy)
PDB

7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR006846 Small ribosomal subunit protein eS30

IPR019954 Ubiquitin conserved site

IPR019956 Ubiquitin domain

IPR000626 Ubiquitin-like domain

IPR029071 Ubiquitin-like domain superfamily

IPR039415 Ubiquitin-like protein FUBI
GlyGen

P62862 1 site, 1 O-linked glycan (1 site)

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All nucleic 295

Genomic 2

cDNA 293

Microarray probesets 4

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MGD-MRK-19396

Summaries

All 41

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 6
Earliest

J:42311 Michiels L, et al., fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus. Oncogene. 1993 Sep;8(9):2537-46
Latest

J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

TSS for Fau:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154545	Chr19:6107922-6107944 (+)	-44 bp
Tssr154546	Chr19:6107955-6107988 (+)	-5 bp
Tssr154547	Chr19:6108164-6108236 (+)	223 bp
Tssr154548	Chr19:6108240-6108260 (+)	273 bp
Tssr154549	Chr19:6108265-6108276 (+)	294 bp
Tssr154550	Chr19:6108351-6108389 (+)	393 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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