Cd1 Complex/Cluster/Region Detail

Summary

• Symbol
  Cd1
• Name
  CD1 antigen complex

• Feature Type
  complex/cluster/region
• IDs
  MGI:102561
  NCBI Gene: 111334
• Cluster Members
  Cd1d2, Cd1d1 (2 members)

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 3, Syntenic
• Mapping Data
  4 experiments

Strain
Comparison

• PCR
  1

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotypes from 1 allele in 2 genetic backgrounds
  125 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  7 strains or lines available

Animals homozygous for a mutation in this gene lack an NK-like cell subset (HSA<-/low>, NK1.1+, TCRint, CD44high, CD122+) of thymocytes. TCR cross-linking and anti-CD3 stimulation fails to induce IL-4 production.

Expression

• cDNA Data
  1

Sequences &
Gene Models

• NCBI Gene
  111334

Molecular
Reagents

• All nucleic 2

  cDNA 1

  Primer pair 1

Other
Accession IDs

MGD-MRK-19430

References

• Summaries
  All 146

  Phenotypes 125
• Earliest
  J:10078 Roopenian DC, et al., Responses against antigens encoded by the H-3 histocompatibility locus: antigens stimulating class I MHC- and class II MHC-restricted T cells are encoded by separate genes. Immunogenetics. 1989;30(5):335-43
• Latest
  J:338437 Luo J, et al., Lipids regulate peripheral serotonin release via gut CD1d. Immunity. 2023 Jul 11;56(7):1533-1547.e7

Cd1 Cluster contains:

More Data for these features

Member	Feature Type	Location
Cd1d2, CD1d2 antigen	polymorphic pseudogene	Chr3:86893875-86896843 (+)
Cd1d1, CD1d1 antigen	protein coding gene	Chr3:86903141-86906748 (-)