Cdc34 MGI Mouse Gene Detail - MGI:102657

Symbol

Cdc34
Name

cell division cycle 34
Synonyms

UBE2R1

Feature Type

protein coding gene
IDs

MGI:102657
NCBI Gene: 216150
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr10:79518029-79524232 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

4 experiments

SNPs within 2kb

137 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102657	protein coding gene	Chr10:79518029-79524232 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017452	protein coding gene	Chr10:80220495-80227086 (+)
A/J	MGP_AJ_G0017430	protein coding gene	Chr10:77432949-77439148 (+)
AKR/J	MGP_AKRJ_G0017391	protein coding gene	Chr10:79537606-79543805 (+)
BALB/cJ	MGP_BALBcJ_G0017392	protein coding gene	Chr10:77661005-77667204 (+)
C3H/HeJ	MGP_C3HHeJ_G0017215	protein coding gene	Chr10:79645487-79651686 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017846	protein coding gene	Chr10:82993221-82999420 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015534	protein coding gene	Chr10:73661327-73667591 (+)
CAST/EiJ	MGP_CASTEiJ_G0016782	protein coding gene	Chr10:79821800-79828799 (+)
CBA/J	MGP_CBAJ_G0017187	protein coding gene	Chr10:86218148-86224347 (+)
DBA/2J	MGP_DBA2J_G0017293	protein coding gene	Chr10:76650594-76656793 (+)
FVB/NJ	MGP_FVBNJ_G0017287	protein coding gene	Chr10:75811393-75817592 (+)
LP/J	MGP_LPJ_G0017364	protein coding gene	Chr10:80701194-80709312 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017313	protein coding gene	Chr10:88197859-88204058 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017887	protein coding gene	Chr10:79518376-79524575 (+)
PWK/PhJ	MGP_PWKPhJ_G0016563	protein coding gene	Chr10:76507942-76514313 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016352	protein coding gene	Chr10:78491990-78498285 (+)
WSB/EiJ	MGP_WSBEiJ_G0016842	protein coding gene	Chr10:79546465-79554309 (+)

Human Ortholog

CDC34, cell division cycle 34, ubiqiutin conjugating enzyme

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDC34, cell division cycle 34, ubiqiutin conjugating enzyme
Synonyms

E2-CDC34, UBC3, UBCH3, UBE2R1
Links

HGNC:1734

NCBI Gene ID: 997

neXtProt AC: NX_P49427

UniProt: P49427
Chr Location

19p13.3; chr19:531760-542092 (+) GRCh38

MGI Vertebrate Homology

Cdc34 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CDC34
Gene Tree

Cdc34

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

20
Targeted

3
Genomic Mutations

1 involving Cdc34
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

25
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

47
cDNA Data

128
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDC34

Xenbase cdc34

ZFIN cdc34a, cdc34b

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All Sequences

70
RefSeq

10
UniProt

7
CCDS

CCDS23983.1, CCDS88049.1

Ensembl

ENSMUSG00000020307 (Evidence)
NCBI Gene

216150

			Length	Strain/Species	Flank
genomic	216150	NCBI Gene Model \| MGI Sequence Detail	6204	C57BL/6J	± kb
transcript	NM_177613	RefSeq \| MGI Sequence Detail	1295	ZRU/MplStud
polypeptide	Q8CFI2	UniProt \| EBI \| MGI Sequence Detail	235	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000005200 ubiquitin-conjugating enzyme E2 R1

(term hierarchy)
EC

2.3.2.23, 2.3.2.24
InterPro Domains

IPR050113 Ubiquitin-conjugating enzyme

IPR023313 Ubiquitin-conjugating enzyme, active site

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like
GlyGen

Q8CFI2 1 site, 1 O-linked glycan (1 site)

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All nucleic 128

cDNA 128

Microarray probesets 3

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MGD-MRK-19551, MGI:2143587

Summaries

All 52

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cdc34:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3269	Chr10:79516848-79516874 (+)	-1,168 bp
Tssr94367	Chr10:79517618-79517647 (+)	-396 bp
Tssr3270	Chr10:79517659-79517667 (+)	-366 bp
Tssr94368	Chr10:79517981-79517995 (+)	-41 bp
Tssr94369	Chr10:79518003-79518064 (+)	5 bp
Tssr94370	Chr10:79518066-79518081 (+)	45 bp
Tssr94371	Chr10:79518140-79518156 (+)	119 bp
Tssr94372	Chr10:79518204-79518242 (+)	194 bp
Tssr3271	Chr10:79522273-79522280 (+)	4,248 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24