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Crym Gene Detail
Summary
  • Symbol
    Crym
  • Name
    crystallin, mu
  • Feature Type
    protein coding gene
  • IDs
    MGI:102675
    NCBI Gene: 12971
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:119785603-119801212 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 64.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    592 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102675
 protein coding gene Chr7:119785603-119801334 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032926
 protein coding gene Chr7:124142077-124164536 (-)
A/J MGP_AJ_G0032909
 protein coding gene Chr7:120923865-120940434 (-)
AKR/J MGP_AKRJ_G0032841
 protein coding gene Chr7:124041660-124057346 (-)
BALB/cJ MGP_BALBcJ_G0032914
 protein coding gene Chr7:120658285-120674004 (-)
C3H/HeJ MGP_C3HHeJ_G0032624
 protein coding gene Chr7:123950837-123966816 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033420
 protein coding gene Chr7:129039267-129054932 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030392
 protein coding gene Chr7:122340401-122356193 (-)
CAST/EiJ MGP_CASTEiJ_G0031952
 protein coding gene Chr7:115708510-115724717 (-)
CBA/J MGP_CBAJ_G0032597
 protein coding gene Chr7:133365695-133383918 (-)
DBA/2J MGP_DBA2J_G0032749
 protein coding gene Chr7:118973923-118990247 (-)
FVB/NJ MGP_FVBNJ_G0032702
 protein coding gene Chr7:118801804-118817432 (-)
LP/J MGP_LPJ_G0032843
 protein coding gene Chr7:125594049-125610186 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032734
 protein coding gene Chr7:134807737-134826138 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033440
 protein coding gene Chr7:123027965-123043664 (-)
PWK/PhJ MGP_PWKPhJ_G0031660
 protein coding gene Chr7:111889272-111906019 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031506
 protein coding gene Chr7:109773338-109790552 (-)
WSB/EiJ MGP_WSBEiJ_G0032065
 protein coding gene Chr7:123919838-123936721 (-)



Homology
more
  • Human Ortholog
    CRYM, crystallin mu
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRYM, crystallin mu
  • Synonyms
    DFNA40, THBP
  • Links
    NCBI Gene ID: 1428
    neXtProt AC: NX_Q14894
    UniProt: Q14894

  • Chr Location
    16p12.2; chr16:21238874-21303083 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CRYM associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
At the euthyroid state, homozygotes display a normal growth curve, heart rate and hearing ability but have significantly reduced serum concentrations of triiodothyronine (T3) and thyroxine (T4).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1101
  • Tissues
    183
  • cDNA Data
    38
  • Literature Summary
    47
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12971 NCBI Gene Model | MGI Sequence Detail 15610 C57BL/6J ±  kb
    transcript NM_016669 RefSeq | MGI Sequence Detail 1278 ZRU/MplStud  
    polypeptide O54983 UniProt | EBI | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 39
      Primer pair 5
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19578
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 47
      Gene Ontology 7
      Phenotypes 16
    • Earliest
      J:3554 Chen H, et al., Localization of the human gene for mu-crystallin to chromosome 16p. Genomics. 1992 Dec;14(4):1115-6
    • Latest
      J:345957 Ollivier M, et al., Crym-positive striatal astrocytes gate perseverative behaviour. Nature. 2024 Mar;627(8003):358-366
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory