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Llgl1 Gene Detail
Summary
  • Symbol
    Llgl1
  • Name
    LLGL1 scribble cell polarity complex component
  • Synonyms
    Lgl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102682
    NCBI Gene: 16897
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60590549-60605012 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.81 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102682
 protein coding gene Chr11:60590501-60605012 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018421
 protein coding gene Chr11:60612499-60628664 (+)
A/J MGP_AJ_G0018390
 protein coding gene Chr11:58382747-58397175 (+)
AKR/J MGP_AKRJ_G0018360
 protein coding gene Chr11:60236208-60250688 (+)
BALB/cJ MGP_BALBcJ_G0018361
 protein coding gene Chr11:58679700-58694147 (+)
C3H/HeJ MGP_C3HHeJ_G0018174
 protein coding gene Chr11:60170735-60185163 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018813
 protein coding gene Chr11:62535218-62549665 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016459
 protein coding gene Chr11:55525631-55539823 (+)
CAST/EiJ MGP_CASTEiJ_G0017731
 protein coding gene Chr11:60267960-60282393 (+)
CBA/J MGP_CBAJ_G0018148
 protein coding gene Chr11:65256045-65270473 (+)
DBA/2J MGP_DBA2J_G0018257
 protein coding gene Chr11:57969220-57983707 (+)
FVB/NJ MGP_FVBNJ_G0018248
 protein coding gene Chr11:57631495-57645942 (+)
LP/J MGP_LPJ_G0018330
 protein coding gene Chr11:61192365-61206875 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018272
 protein coding gene Chr11:66310867-66328487 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018854
 protein coding gene Chr11:60326872-60341300 (+)
PWK/PhJ MGP_PWKPhJ_G0017504
 protein coding gene Chr11:58546862-58561285 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017294
 protein coding gene Chr11:60145483-60159877 (+)
WSB/EiJ MGP_WSBEiJ_G0017783
 protein coding gene Chr11:59944606-59963334 (+)



Homology
more
  • Human Ortholog
    LLGL1, LLGL scribble cell polarity complex component 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LLGL1, LLGL scribble cell polarity complex component 1
  • Synonyms
    DLG4, HUGL, HUGL-1, HUGL1, Lgl1, LLGL, Mgl1
  • Links
    NCBI Gene ID: 3996
    neXtProt AC: NX_Q15334
    UniProt: Q15334

  • Chr Location
    17p11.2; chr17:18225635-18244875 (+)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice die neonatally exhibiting hydroencephaly. Neural progenitor cell physiology is abnormal, resulting in a loss of cell polarity and the development of neuroepithelial rosette-like structures throughout the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    890
  • Tissues
    165
  • cDNA Data
    169
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020536 Ensembl Gene Model | MGI Sequence Detail 14464 C57BL/6J ±  kb
    transcript ENSMUST00000052346 Ensembl | MGI Sequence Detail 4303 Not Applicable  
    polypeptide ENSMUSP00000060749 Ensembl | MGI Sequence Detail 1062 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000009847 lethal(2) giant larvae protein homolog 1
      (term hierarchy)
    • InterPro Domains
      IPR000664 Lethal(2) giant larvae protein
      IPR013577 Lethal giant larvae homologue 2
      IPR013905 Lethal giant larvae (Lgl)-like, C-terminal domain
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q80Y17 2 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 182
      Genomic 10
      cDNA 169
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19585, MGI:2144129
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 15
      Diseases 2
      Gene Ontology 11
      Phenotypes 36
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:348769 Hou C, et al., Role of LGL1 in cerebellar primordium of embryonic mice. Neuroreport. 2024 Apr 3;35(6):374-379
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory