About   Help   FAQ
Itga7 Gene Detail
Summary
  • Symbol
    Itga7
  • Name
    integrin alpha 7
  • Synonyms
    [a]7, alpha7
  • Feature Type
    protein coding gene
  • IDs
    MGI:102700
    NCBI Gene: 16404
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128769645-128794155 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 77.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    740 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102700
 protein coding gene Chr10:128769633-128794155 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017891
 protein coding gene Chr10:132734817-132760282 (+)
A/J MGP_AJ_G0017866
 protein coding gene Chr10:127391678-127416124 (+)
AKR/J MGP_AKRJ_G0017829
 protein coding gene Chr10:131111080-131135479 (+)
BALB/cJ MGP_BALBcJ_G0017830
 protein coding gene Chr10:127750583-127775388 (+)
C3H/HeJ MGP_C3HHeJ_G0017653
 protein coding gene Chr10:131282911-131307360 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018285
 protein coding gene Chr10:137208140-137232648 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015963
 protein coding gene Chr10:121296919-121322205 (+)
CAST/EiJ MGP_CASTEiJ_G0017214
 protein coding gene Chr10:132015342-132040020 (+)
CBA/J MGP_CBAJ_G0017623
 protein coding gene Chr10:142806764-142831279 (+)
DBA/2J MGP_DBA2J_G0017729
 protein coding gene Chr10:126447971-126472405 (+)
FVB/NJ MGP_FVBNJ_G0017724
 protein coding gene Chr10:125369408-125394555 (+)
LP/J MGP_LPJ_G0017803
 protein coding gene Chr10:133312358-133337014 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017752
 protein coding gene Chr10:145360024-145384620 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018325
 protein coding gene Chr10:131216193-131240638 (+)
PWK/PhJ MGP_PWKPhJ_G0016999
 protein coding gene Chr10:126717279-126741987 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016788
 protein coding gene Chr10:130332682-130357520 (+)
WSB/EiJ MGP_WSBEiJ_G0017273
 protein coding gene Chr10:131448313-131474161 (+)



Homology
more
  • Human Ortholog
    ITGA7, integrin subunit alpha 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA7, integrin subunit alpha 7
  • Links
    NCBI Gene ID: 3679
    neXtProt AC: NX_Q13683
    UniProt: Q13683

  • Chr Location
    12q13.2; chr12:55684568-55716404 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Itga7 mouse models; 3 with human ITGA7 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 3 genetic backgrounds
    31 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions of this gene display characteristics of muscular dystrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    948
  • Tissues
    132
  • cDNA Data
    52
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025348 Ensembl Gene Model | MGI Sequence Detail 24511 C57BL/6J ±  kb
    transcript ENSMUST00000240553 Ensembl | MGI Sequence Detail 4191 Not Applicable  
    polypeptide ENSMUSP00000159495 Ensembl | MGI Sequence Detail 1180 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000009132 integrin alpha-7
      (term hierarchy)
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048286 Integrin alpha, third immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
    • GlyGen
      Q61738 8 sites, 12 N-linked glycans (7 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 3
      cDNA 54
      Primer pair 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-19604
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 40
      Diseases 2
      Gene Ontology 10
      Phenotypes 38
    • Earliest
      J:35484 Kaufman SJ, et al., Expression of a developmentally regulated antigen on the surface of skeletal and cardiac muscle cells. J Cell Biol. 1985 Jun;100(6):1977-87
    • Latest
      J:341272 Chen Z, et al., The alpha7 integrin subunit in astrocytes promotes endothelial blood-brain barrier integrity. Development. 2023 Mar 15;150(6):dev201356
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory