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Gng4 Gene Detail
Summary
  • Symbol
    Gng4
  • Name
    guanine nucleotide binding protein (G protein), gamma 4
  • Synonyms
    4
  • Feature Type
    protein coding gene
  • IDs
    MGI:102703
    NCBI Gene: 14706
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:13958644-14002480 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 5.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1685 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102703
 protein coding gene Chr13:13958644-14002481 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020237
 protein coding gene Chr13:10733823-10781014 (+)
A/J MGP_AJ_G0020195
 protein coding gene Chr13:10684347-10730112 (+)
AKR/J MGP_AKRJ_G0020169
 protein coding gene Chr13:10791641-10838591 (+)
BALB/cJ MGP_BALBcJ_G0020181
 protein coding gene Chr13:10669394-10713684 (+)
C3H/HeJ MGP_C3HHeJ_G0019985
 protein coding gene Chr13:10958342-11003747 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020625
 protein coding gene Chr13:11318919-11369055 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018231
 protein coding gene Chr13:9445911-9489012 (+)
CAST/EiJ MGP_CASTEiJ_G0019519
 protein coding gene Chr13:10596845-10643726 (+)
CBA/J MGP_CBAJ_G0019949
 protein coding gene Chr13:11670455-11719202 (+)
DBA/2J MGP_DBA2J_G0020068
 protein coding gene Chr13:10332692-10376968 (+)
FVB/NJ MGP_FVBNJ_G0020049
 protein coding gene Chr13:10057899-10102060 (+)
LP/J MGP_LPJ_G0020138
 protein coding gene Chr13:10935051-10979683 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020086
 protein coding gene Chr13:11771701-11817412 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020652
 protein coding gene Chr13:10595708-10645383 (+)
PWK/PhJ MGP_PWKPhJ_G0019282
 protein coding gene Chr13:10425250-10471119 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019089
 protein coding gene Chr13:9790252-9834331 (+)
WSB/EiJ MGP_WSBEiJ_G0019580
 protein coding gene Chr13:10619223-10664305 (+)



Homology
more
  • Human Ortholog
    GNG4, G protein subunit gamma 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNG4, G protein subunit gamma 4
  • Synonyms
    HG3C
  • Links
    NCBI Gene ID: 2786
    neXtProt AC: NX_P50150
    UniProt: P50150

  • Chr Location
    1q42.3; chr1:235547685-235650754 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    22
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14706 NCBI Gene Model | MGI Sequence Detail 43837 C57BL/6J ±  kb
transcript NM_010317 RefSeq | MGI Sequence Detail 3200 ZRU/MplStud  
polypeptide P50153 UniProt | EBI | MGI Sequence Detail 75 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000008109 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
    (term hierarchy)
  • InterPro Domains
    IPR015898 G-protein gamma-like domain
    IPR036284 G-protein gamma-like domain superfamily
    IPR001770 G-protein, gamma subunit
  • GlyGen
    P50153 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 29
    Genomic 3
    cDNA 22
    Primer pair 3
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-19607
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:14657 Gautam N, et al., G protein diversity is increased by associations with a variety of gamma subunits. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7973-7
  • Latest
    J:347348 Yim YY, et al., Specificities of Gbetagamma subunits for the SNARE complex before and after stimulation of alpha(2a)-adrenergic receptors. Sci Signal. 2021 Dec 21;14(714):eabc4970
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory