Cryba4 MGI Mouse Gene Detail - MGI:102716

Symbol

Cryba4
Name

crystallin, beta A4

Feature Type

protein coding gene
IDs

MGI:102716
NCBI Gene: 12959
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr5:112394359-112400384 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 54.62 cM
Mapping Data

7 experiments

SNPs within 2kb

203 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102716	protein coding gene	Chr5:112394358-112411411 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029900	protein coding gene	Chr5:114819490-114825489 (-)
A/J	MGP_AJ_G0029866	protein coding gene	Chr5:110348686-110354823 (-)
AKR/J	MGP_AKRJ_G0029804	protein coding gene	Chr5:113855756-113861767 (-)
BALB/cJ	MGP_BALBcJ_G0029877	protein coding gene	Chr5:111707805-111713850 (-)
C3H/HeJ	MGP_C3HHeJ_G0029597	protein coding gene	Chr5:114295403-114301403 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030330	protein coding gene	Chr5:119304940-119310966 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027559	protein coding gene	Chr5:105172278-105178463 (-)
CAST/EiJ	MGP_CASTEiJ_G0029005	protein coding gene	Chr5:113196410-113202431 (-)
CBA/J	MGP_CBAJ_G0029564	protein coding gene	Chr5:123781629-123787631 (-)
DBA/2J	MGP_DBA2J_G0029714	protein coding gene	Chr5:110414964-110420993 (-)
FVB/NJ	MGP_FVBNJ_G0029671	protein coding gene	Chr5:109137106-109143140 (-)
LP/J	MGP_LPJ_G0029802	protein coding gene	Chr5:115387217-115393587 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029702	protein coding gene	Chr5:128361343-128367365 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030371	protein coding gene	Chr5:113290092-113296112 (-)
PWK/PhJ	MGP_PWKPhJ_G0028719	protein coding gene	Chr5:109023344-109029359 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028557	protein coding gene	Chr5:110773868-110779876 (-)
WSB/EiJ	MGP_WSBEiJ_G0029081	protein coding gene	Chr5:113802997-113809006 (-)

Human Ortholog

CRYBA4, crystallin beta A4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRYBA4, crystallin beta A4
Synonyms

CTRCT23, CYRBA4, MCOPCT4
Links

HGNC:2396

NCBI Gene ID: 1413

neXtProt AC: NX_P53673

UniProt: P53673
Chr Location

22q12.1; chr22:26590220-26630669 (+) GRCh38

MGI Vertebrate Homology

Cryba4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CRYBA4
Gene Tree

Cryba4

Diseases

1 with human CRYBA4 associations

				Human Disease	Mouse Models
				cataract 23 IDs cataract 23 DOID:0110271 ICD10CM:Q12.0 OMIM:610425

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

8
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Cryba4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

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All GO Annotations

11
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

3
cDNA Data

85
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cryba4

ZFIN cryba4

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All Sequences

44
RefSeq

6
UniProt

5
CCDS

CCDS19536.1, CCDS84931.1

Ensembl

ENSMUSG00000066975 (Evidence)
NCBI Gene

12959

			Length	Strain/Species	Flank
genomic	ENSMUSG00000066975	Ensembl Gene Model \| MGI Sequence Detail	6026	C57BL/6J	± kb
transcript	ENSMUST00000086629	Ensembl \| MGI Sequence Detail	746	Not Applicable
polypeptide	ENSMUSP00000083826	Ensembl \| MGI Sequence Detail	196	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000005910 beta-crystallin A4

(term hierarchy)
InterPro Domains

IPR001064 Beta/gamma crystallin

IPR050252 Beta/Gamma-Crystallin

IPR011024 Gamma-crystallin-like

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All nucleic 89

Genomic 1

cDNA 85

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-19620

Summaries

All 47

Developmental Gene Expression 6

Gene Ontology 4

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:331971 Martynova E, et al., Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3. Open Biol. 2019 Dec;9(12):190220

TSS for Cryba4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52558	Chr5:112400379-112400391 (-)	-1 bp
Tssr52557	Chr5:112400316-112400329 (-)	61 bp
Tssr52556	Chr5:112399087-112399103 (-)	1,289 bp
Tssr52555	Chr5:112399074-112399085 (-)	1,304 bp
Tssr52554	Chr5:112399052-112399071 (-)	1,322 bp
Tssr52553	Chr5:112399003-112399043 (-)	1,361 bp
Tssr52552	Chr5:112397190-112397206 (-)	3,186 bp
Tssr52551	Chr5:112394402-112394420 (-)	5,973 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24