Dck MGI Mouse Gene Detail - MGI:102726

Symbol

Dck
Name

deoxycytidine kinase

Feature Type

protein coding gene
IDs

MGI:102726
NCBI Gene: 13178
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr5:88912872-88931136 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 43.96 cM, cytoband E2
Mapping Data

2 experiments

SNPs within 2kb

665 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102726	protein coding gene	Chr5:88912855-88931140 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029713	protein coding gene	Chr5:89774950-89792818 (+)
A/J	MGP_AJ_G0029679	protein coding gene	Chr5:86235839-86254719 (+)
AKR/J	MGP_AKRJ_G0029625	protein coding gene	Chr5:89069493-89087795 (+)
BALB/cJ	MGP_BALBcJ_G0029689	protein coding gene	Chr5:87140915-87159262 (+)
C3H/HeJ	MGP_C3HHeJ_G0029412	protein coding gene	Chr5:89421724-89439812 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030143	protein coding gene	Chr5:93421898-93443878 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027379	protein coding gene	Chr5:82039834-82058266 (+)
CAST/EiJ	MGP_CASTEiJ_G0028822	protein coding gene	Chr5:88842356-88861912 (+)
CBA/J	MGP_CBAJ_G0029381	protein coding gene	Chr5:96543586-96563692 (+)
DBA/2J	MGP_DBA2J_G0029526	protein coding gene	Chr5:86297318-86316442 (+)
FVB/NJ	MGP_FVBNJ_G0029485	protein coding gene	Chr5:85214728-85233675 (+)
LP/J	MGP_LPJ_G0029614	protein coding gene	Chr5:90175961-90195764 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029514	protein coding gene	Chr5:101560377-101596954 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030177	protein coding gene	Chr5:88585473-88606085 (+)
PWK/PhJ	MGP_PWKPhJ_G0028541	protein coding gene	Chr5:85382228-85400938 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028376	protein coding gene	Chr5:88022838-88042016 (+)
WSB/EiJ	MGP_WSBEiJ_G0028901	protein coding gene	Chr5:88975791-88995979 (+)

Human Ortholog

DCK, deoxycytidine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DCK, deoxycytidine kinase
Links

HGNC:2704

NCBI Gene ID: 1633

neXtProt AC: NX_P27707

UniProt: P27707
Chr Location

4q13.3; chr4:70992538-71030914 (+) GRCh38

MGI Vertebrate Homology

Dck stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DCK
Protein SuperFamily

DNK
Gene Tree

Dck

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Phenotype Summary

33 phenotypes from 4 alleles in 4 genetic backgrounds
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (ENU)

2
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

8
Radiation induced

1
Spontaneous

1
Targeted

4
Genomic Mutations

4 involving Dck
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene have profound defects in lymphopoiesis. Thymic T cell number and overall lymphocyte number are greatly reduced.

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All GO Annotations

29
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

807
Tissues

101
cDNA Data

15
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dck, dck.2

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All Sequences

41
RefSeq

2
UniProt

3
CCDS

CCDS19405.1

Ensembl

ENSMUSG00000029366 (Evidence)
NCBI Gene

13178

			Length	Strain/Species	Flank
genomic	13178	NCBI Gene Model \| MGI Sequence Detail	18265	C57BL/6J	± kb
transcript	NM_007832	RefSeq \| MGI Sequence Detail	3057	C57BL/6
polypeptide	P43346	UniProt \| EBI \| MGI Sequence Detail	260	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006309 deoxycytidine kinase

(term hierarchy)
EC

2.7.1.113, 2.7.1.74, 2.7.1.76
InterPro Domains

IPR002624 Deoxynucleoside kinase

IPR031314 Deoxynucleoside kinase domain

IPR050566 Deoxyribonucleoside Kinase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 5

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MGD-MRK-19630

Summaries

All 52

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 20
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Dck:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47029	Chr5:88912787-88912805 (+)	-76 bp
Tssr47030	Chr5:88912842-88912854 (+)	-24 bp
Tssr47031	Chr5:88912863-88912889 (+)	4 bp
Tssr47032	Chr5:88912895-88912913 (+)	32 bp
Tssr47033	Chr5:88913008-88913019 (+)	142 bp
Tssr47034	Chr5:88913028-88913050 (+)	167 bp
Tssr47035	Chr5:88913051-88913058 (+)	183 bp
Tssr47036	Chr5:88913059-88913070 (+)	193 bp
Tssr47037	Chr5:88913071-88913082 (+)	205 bp
Tssr47038	Chr5:88913708-88913711 (+)	838 bp
Tssr47039	Chr5:88929820-88929832 (+)	16,954 bp
Tssr47040	Chr5:88929888-88929899 (+)	17,022 bp
Tssr47041	Chr5:88930051-88930062 (+)	17,185 bp
Tssr47042	Chr5:88930125-88930160 (+)	17,271 bp
Tssr47043	Chr5:88930396-88930432 (+)	17,542 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24